Document Detail

Androstenedione, dehydroepiandrosterone sulfate, and estradiol levels throughout female puberty: relation to height velocity.
MedLine Citation:
PMID:  9402243     Owner:  NLM     Status:  MEDLINE    
Sex steroids are important contributors to the pubertal growth spurt. Both androgens and estrogens have been related to this moment of rapid growth, but the role of estrogens is thought to be the most important one. Since exogenous estrogens are not capable to induce an appropriate growth spurt in girls, there might be an additional contributing factor involved. In a recent pilot study of 32 healthy pubertal girls, we found that the peak height velocity (HV) is preceded by relatively high levels of dehydroepiandrosterone sulfate and androstenedione (delta4A) as compared with the end-pubertal level. In the present study we evaluated HV in relation to dehydroepiandrosterone sulfate and delta4A levels in 149 healthy girls of various Tanner stages. HV was correlated with delta4A and estradiol levels in Tanner stages I-III. These results suggest that, like estrogens, delta4A might be an important stimulator of the female growth spurt.
J Rotteveel; C de Ridder; E Schoute; H A Delemarre-van de Waal
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Hormone research     Volume:  48     ISSN:  0301-0163     ISO Abbreviation:  Horm. Res.     Publication Date:  1997  
Date Detail:
Created Date:  1998-01-30     Completed Date:  1998-01-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0366126     Medline TA:  Horm Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  263-7     Citation Subset:  IM    
Department of Pediatrics, University Hospital Vrije Universiteit, Amsterdam, The Netherlands.
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MeSH Terms
Androstenedione / blood*
Body Weight / physiology*
Dehydroepiandrosterone / blood*
Estradiol / blood*
Growth / physiology*
Puberty / physiology*
Reference Values
Reg. No./Substance:
50-28-2/Estradiol; 53-43-0/Dehydroepiandrosterone; 63-05-8/Androstenedione

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