| Andrographolide attenuates tumor necrosis factor-alpha-induced insulin resistance in 3T3-L1 adipocytes. | |
| | |
MedLine Citation:
|
PMID: 20943205 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Andrographolide (AG), the primary bioactive component of Andrographils paniculate Nees, has showed an anti-diabetic effect. However, the molecular mechanism has not been clarified. In this study, we demonstrated that AG increased glucose uptake in 3T3-L1 cells in a time- and dosedependent manner. The activation of insulin signaling by AG was initiated from phosphotyrosine of IRS-1 and further passed on through phosphatidylinositol 3-kinase (PI3K) and the downstream signaling cascades. Moreover importantly, pretreatment cells with AG suppressed the TNF-α induced activation of NF-κB signaling pathway and its downstream inflammatory factors expression, therefore ameliorating insulin resistance. In conclusion, AG can improve insulin sensitivity through inhibition of NF-κB pathway. These findings are helpful in understanding the anti-diabetic properties of AG and can be of interest for the therapeutic application of AG in glucose controlling. |
| | |
Authors:
|
Lina Jin; Guojun Shi; Guang Ning; Xiaoying Li; Zhiguo Zhang |
Related Documents
:
|
18591395 - Mir-375 targets 3'-phosphoinositide-dependent protein kinase-1 and regulates glucose-in... 20299475 - Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulati... 19017805 - Inducible and reversible gene silencing by stable integration of an shrna-encoding lent... 8674815 - Wortmannin and ly294002 inhibit the insulin-induced down-regulation of irs-1 in 3t3-l1 ... 8799485 - Hypoglycemic and aldose reductase activity of polichia campestris. 15277385 - Splanchnic cortisol production occurs in humans: evidence for conversion of cortisone t... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-11 |
Journal Detail:
|
Title: Molecular and cellular endocrinology Volume: 332 ISSN: 1872-8057 ISO Abbreviation: Mol. Cell. Endocrinol. Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2010-12-28 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7500844 Medline TA: Mol Cell Endocrinol Country: Ireland |
Other Details:
|
Languages: eng Pagination: 134-9 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
|
Laboratory of Endocrinology and Metabolism, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and Shanghai Jiao Tong University School of Medicine, Shanghai, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: miR-29a levels are elevated in the db/db mice liver and its overexpression leads to attenuation of i...
Next Document: Age affects reciprocal cellular interactions in neuromuscular synapses following peripheral nerve in...