| Androgens suppress antigen-specific T cell responses and IFN-γ production during intracranial LCMV infection. | |
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MedLine Citation:
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PMID: 20619904 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intracranial (i.c.) lymphocytic choriomeningitis virus (LCMV) infection of mice results in T cell-driven anorexia and weight loss, which is diminished in males compared to females. We investigated sex-specific effects on antigen-presenting cells (APCs) and T cells after i.c. LCMV infection. Numbers of LCMV-specific T cells, APC activation, and levels of inflammatory cytokines and chemokines in CSF were decreased in males compared to females. Orchidectomy enhanced these immune parameters in males, while dihydrotestosterone treatment of orchidectomized males and intact females decreased some of these parameters. These data suggest that qualitative and quantitative effects of androgens on APCs and T cells may contribute to the well-known, but poorly understood sex differences in immunity and autoimmunity. |
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Authors:
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Adora A Lin; Sara E Wojciechowski; David A Hildeman |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of neuroimmunology Volume: 226 ISSN: 1872-8421 ISO Abbreviation: J. Neuroimmunol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-10 Completed Date: 2010-10-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8109498 Medline TA: J Neuroimmunol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 8-19 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Division of Immunobiology, Cincinnati Children's Hospital, 3333 Burnet Ave., MLC 7038, Cincinnati, OH 45229, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aldosterone
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analogs & derivatives,
therapeutic use Androgens / pharmacology*, therapeutic use Animals Antigen-Presenting Cells / drug effects* Antigens, CD45 / metabolism Brain / pathology, virology Cytokines / metabolism Eating / drug effects Enzyme-Linked Immunosorbent Assay / methods Estradiol / blood Female Interferon-gamma / metabolism* Lymphocytic Choriomeningitis / blood, drug therapy, pathology*, physiopathology Lymphocytic choriomeningitis virus / pathogenicity Male Mice Mice, Knockout Myosin Heavy Chains / deficiency Neurons / drug effects, immunology, metabolism Orchiectomy / methods Sex Factors Statistics, Nonparametric T-Lymphocytes / drug effects*, immunology Testosterone / blood Weight Loss / physiology |
| Grant Support | |
ID/Acronym/Agency:
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NS051798/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Androgens; 0/Cytokines; 0/Myosin Heavy Chains; 0/beta myosin heavy chain protein, mouse; 50-28-2/Estradiol; 52-39-1/Aldosterone; 58-22-0/Testosterone; 6005-92-1/5-dihydroaldosterone; 82115-62-6/Interferon-gamma; EC 3.1.3.48/Antigens, CD45 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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