Document Detail

Androgens modulate endplate size and ACh receptor density at synapses in rat levator ani muscle.
MedLine Citation:
PMID:  2754433     Owner:  NLM     Status:  MEDLINE    
The dorsal bulbocavernosus or "levator ani" muscle of the rat is highly responsive to androgens. Both the muscle and the motoneurons which innervate it contain high concentrations of androgen receptors. The neuromuscular synapses in this muscle are also affected by changing androgen levels. In particular, the total number of ACh receptors (AChRs) in the muscle is lower in males that have been castrated, and it increases after treatment with the androgens, testosterone and 5 alpha-dihydrotestosterone. An examination of individual endplates using histochemistry and quantitative autoradiography suggested that the reduction in AChR number following castration is caused by reductions in both the size of endplates and in the density of AChRs at each synapse.
W V Bleisch; A Harrelson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurobiology     Volume:  20     ISSN:  0022-3034     ISO Abbreviation:  J. Neurobiol.     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-09-05     Completed Date:  1989-09-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0213640     Medline TA:  J Neurobiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  189-202     Citation Subset:  IM    
Rockefeller University, New York, New York 10021.
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MeSH Terms
Cholinesterases / metabolism
Dihydrotestosterone / pharmacology*
Motor Endplate / drug effects,  physiology*
Motor Neurons / drug effects,  physiology
Muscle Development*
Muscles / drug effects,  physiology
Neuromuscular Junction / physiology*
Receptors, Cholinergic / drug effects,  metabolism*
Reference Values
Reg. No./Substance:
0/Receptors, Cholinergic; 521-18-6/Dihydrotestosterone; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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