Document Detail


Androgens associate with blood pressure in pregnant women after term.
MedLine Citation:
PMID:  21933155     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective. To assess possible associations between androgen, estrogen and insulin levels and blood pressure in pregnant women after term, compared to the effect of other well-known factors. Design. Cross-sectional retrospective study. Setting. University Hospital, Trondheim region. Population. Four hundred and eighty-nine post-term women with uncomplicated pregnancies. Methods. Blood pressure measurements and fasting serum samples drawn one week beyond the estimated day of delivery (defined as 41(+ 2) weeks). Main outcome measures. Blood pressure, maternal age, body mass index, parity, smoking habits and serum levels of dehydroepiandrosterone sulphate, androstendione, free testosterone index, estradiol, estriol, progesterone, 17-hydroxy-progesterone, and insulin. Results. In univariable linear regression analyses body mass index, androstendione, free testosterone index and insulin associated positively and parity negatively with both systolic and diastolic blood pressure. In multivariable linear regression analyses systolic blood pressure associated positively with body mass index and free testosterone index, but negatively with parity and 17-hydroxy-progesterone levels, while diastolic blood pressure associated positively with age and free testosterone index, but negatively with parity and 17-hydroxy-progesterone levels. Conclusion. Testosterone may increase blood pressure in pregnant women while 17-hydroxy-progesterone may have the opposite effect.
Authors:
Sven M Carlsen; Runa Heimstad
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-21
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  -     ISSN:  1600-0412     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 The Authors AOGS© 2011 Nordic Federation of Societies of Obstetrics and Gynecology.
Affiliation:
Department of Endocrinology, Department of Obstetrics and Gynecology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway, Unit for Applied Clinical Research, Institute of Cancer Research and Molecular Medicine, and Institute of Laboratory Medicine, Children's and Women's health, Norwegian University of Science and Technology, Trondheim, Norway.
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