| Androgens modulate structure and function of the suprachiasmatic nucleus brain clock. | |
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MedLine Citation:
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PMID: 21363939 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gonadal hormones can modulate circadian rhythms in rodents and humans, and androgen receptors are highly localized within the core region of the mouse suprachiasmatic nucleus (SCN) brain clock. Although androgens are known to modulate neural plasticity in other CNS compartments, the role of androgens and their receptors on plasticity in the SCN is unexplored. In the present study, we ask whether androgens influence the structure and function of the mouse SCN by examining the effects of gonadectomy (GDX) on the structure of the SCN circuit and its responses to light, including induction of clock genes and behavioral phase shifting. We found that after GDX, glial fibrillary acidic protein increased with concomitant decreases in the expression of the synaptic proteins synaptophysin and postsynaptic density 95. We also found that GDX exerts effects on the molecular and behavioral responses to light that are phase dependent. In late night [circadian time (CT)21], GDX increased light-induced mPer1 but not mPer2 expression compared with intact (INT) controls. In contrast, in early night (CT13.5), GDX decreased light induced mPer2 but had no effect on mPer1. At CT13.5, GDX animals also showed larger phase delays than did INT. Treatment of GDX animals with the nonaromatizable androgen dihydrotestosterone restored glial fibrillary acidic protein, postsynaptic density 95, and synaptophysin in the SCN and reinstated the INT pattern of molecular and behavioral responses to light. Together, the results reveal a role for androgens in regulating circuitry in the mouse SCN, with functional consequences for clock gene expression and behavioral responses to photic phase resetting stimuli. |
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Authors:
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Ilia N Karatsoreos; Matthew P Butler; Joseph Lesauter; Rae Silver |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-03-01 |
Journal Detail:
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Title: Endocrinology Volume: 152 ISSN: 1945-7170 ISO Abbreviation: Endocrinology Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-22 Completed Date: 2011-07-22 Revised Date: 2012-05-01 |
Medline Journal Info:
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Nlm Unique ID: 0375040 Medline TA: Endocrinology Country: United States |
Other Details:
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Languages: eng Pagination: 1970-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Psychology, Columbia University, New York, New York 10027, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Androgens
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pharmacology* Animals Biological Clocks / drug effects*, genetics, physiology Blotting, Western Brain / drug effects, metabolism, radiation effects Circadian Rhythm Dihydrotestosterone / pharmacology* Gene Expression / drug effects, radiation effects Glial Fibrillary Acidic Protein / metabolism Guanylate Kinase In Situ Hybridization Intracellular Signaling Peptides and Proteins / metabolism Light Male Membrane Proteins / metabolism Mice Mice, Inbred C57BL Microscopy, Confocal Motor Activity / drug effects, radiation effects Orchiectomy Period Circadian Proteins / genetics Suprachiasmatic Nucleus / drug effects*, metabolism Synaptophysin / metabolism Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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NS37919/NS/NINDS NIH HHS; T32DK07328/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Androgens; 0/Glial Fibrillary Acidic Protein; 0/Intracellular Signaling Peptides and Proteins; 0/Membrane Proteins; 0/Per1 protein, mouse; 0/Per2 protein, mouse; 0/Period Circadian Proteins; 0/Synaptophysin; 521-18-6/Dihydrotestosterone; EC 2.7.4.8/Dlgh4 protein, mouse; EC 2.7.4.8/Guanylate Kinase |
| Comments/Corrections | |
Comment In:
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Endocrinology. 2011 May;152(5):1727-30
[PMID:
21511983
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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