Document Detail

Androgen receptor in early apoptotic follicles in the porcine ovary at pregnancy.
MedLine Citation:
PMID:  16977798     Owner:  NLM     Status:  MEDLINE    
Localization of androgen receptor (AR) was investigated in ovarian follicles developing and undergoing atresia during pregnancy in the pig. Immunohistochemical staining was conducted on ovarian antral follicles isolated on different days of gestation: 10, 18, 32, 50, 70, and 90. Paraffin sections were also subjected to in situ DNA labeling. TUNEL staining revealed the presence of positive follicles on all days of pregnancy but the amount of atretic follicles increased with time. However, even on day 90 of gestation many follicles were normal, with no signs of atresia. In atretic follicles, apoptotic cells were localized predominantly in the granulosa while theca was much less affected. Atretic follicles with many apoptotic cells were negative for AR. Nuclear immunostaining for AR was positive in follicles with limited amount of apoptotic cells. The same relationship was observed in ovarian follicles isolated at various days of pregnancy.
Maria Słomczyńska; Zbigniew Tabarowski; Małgorzata Duda; Małgorzata Burek; Katarzyna Knapczyk
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society     Volume:  44     ISSN:  0239-8508     ISO Abbreviation:  Folia Histochem. Cytobiol.     Publication Date:  2006  
Date Detail:
Created Date:  2006-09-18     Completed Date:  2006-11-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8502651     Medline TA:  Folia Histochem Cytobiol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  185-8     Citation Subset:  IM    
Laboratory of Endocrinology and Tissue Culture , Institute of Zoology, Jagiellonian University, Kraków, Poland.
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MeSH Terms
Apoptosis / physiology*
Follicular Atresia / metabolism
In Situ Nick-End Labeling / methods
Ovarian Follicle / metabolism*
Ovary / cytology,  metabolism*
Pregnancy, Animal
Receptors, Androgen / metabolism*
Tissue Distribution
Reg. No./Substance:
0/Receptors, Androgen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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