Document Detail

Androgen receptor expression is a predictive marker in chemotherapy-treated patients with endocrine receptor-positive primary breast cancers.
MedLine Citation:
PMID:  23392859     Owner:  NLM     Status:  Publisher    
PURPOSE: The androgen receptor (AR) is intensively discussed as a prognostic and/or predictive marker in breast cancer patients. METHODS: We evaluated the value of AR mRNA expression with the Affymetrix HG-U 133A array in 3 different cohorts: a cohort of breast cancer patients who received adjuvant treatment (cohort A; n = 165), a cohort of untreated breast cancer patients (cohort B; n = 200) and a cohort of chemotherapy-treated breast cancer patients with estrogen receptor (ER)-positive tumors (cohort C; n = 223). RESULTS: AR mRNA expression was associated with lower grading (Grades 1 and 2) as well as ER and progesterone receptor (PgR) positivity in all cohorts. In the treated cohort (cohort A), low androgen receptor expression was associated with shorter event-free survival (OR 2,34, 95 % CI 1.01-5.43, p = 0.047) which was not seen in the untreated cohort B. Subgroup analysis revealed that shorter survival of patients with low AR mRNA expression was observed mainly in the ER-positive subgroup of patients treated with adjuvant chemotherapy. In the validation cohort C we could confirm a benefit of chemotherapy for the group of tumors with high AR mRNA expression (5-year event-free survival (EFS) 74 % versus 57 %, p = 0.013). In this cohort, low AR mRNA expression was associated with shorter event-free survival also in multivariate analysis (OR 2.86, 95 % CI 1.29-6.35, p = 0.010) adjusted for HER2, ki-67, tumor size, age and tumor grade. CONCLUSIONS: We provide evidence that AR expression is associated with chemotherapy responsiveness in ER-positive patients.
Isabell Witzel; Monika Graeser; Thomas Karn; Markus Schmidt; Ralph Wirtz; Dina Schütze; Alma Rausch; Fritz Jänicke; Karin Milde-Langosch; Volkmar Müller
Related Documents :
23990589 - Does serum albumin and creatinine predict survival of inpatient palliative care patients?
19525119 - Preoperative radiochemotherapy in the treatment of advanced oral cancer: outcome of 276...
9870639 - Disease stage related in vitro responsiveness of peripheral blood t-lymphocytes in pati...
23141049 - Final results of an eortc-gu cancers group randomized study of maintenance bacillus cal...
23925699 - Autologous hematopoietic stem cell transplantation following high dose chemotherapy for...
25031949 - Myeloid toxicity of cancer treatment.
8500809 - Bone scans in neuroblastoma.
22543199 - Planning hybrid intensity modulated radiation therapy for whole-breast irradiation.
15564829 - Prognostic factors in well-differentiated thyroid carcinoma.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-8
Journal Detail:
Title:  Journal of cancer research and clinical oncology     Volume:  -     ISSN:  1432-1335     ISO Abbreviation:  J. Cancer Res. Clin. Oncol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902060     Medline TA:  J Cancer Res Clin Oncol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Gynecology, University Medical Center, Martinistrasse 52, 20246, Hamburg, Germany,
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Flos Lonicerae Extracts and Chlorogenic Acid Protect Human Umbilical Vein Endothelial Cells from the...
Next Document:  Comparison of the adherence and persistence to inhaled corticosteroids among adult patients with pub...