| Androgen and oestrogen binding in cytosols of human ovarian tumours. | |
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MedLine Citation:
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PMID: 7276800 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The specific retention of androgens and oestrogens by cytoplasmic components of human ovarian tumours was investigated. High-affinity, low-capacity binding of androgens was observed in 88% of tumour specimens and oestrogen binding in 32%. Retention of oestrogens did not occur in the absence of androgen binding. The androgen-binding component, of sedimentation coefficient 7.5-8.5S, showed specificity for 5 alpha-dihydrotestosterone and 17 beta-hydroxy-17 alpha-methyl-estra-4,9,11-trien-3-one (R1881). In some instances, competition for R1881-binding sites indicated the presence of progesterone receptor-like binding. The data presented suggest strongly the existence of androgen and oestrogen receptors in some ovarian tumours and may be relevant to histopathological classification and therapeutic rationales. |
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Authors:
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T C Hamilton; P Davies; K Griffiths |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of endocrinology Volume: 90 ISSN: 0022-0795 ISO Abbreviation: J. Endocrinol. Publication Date: 1981 Sep |
Date Detail:
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Created Date: 1981-11-22 Completed Date: 1981-11-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375363 Medline TA: J Endocrinol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 421-31 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Androgens
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metabolism* Binding, Competitive Centrifugation, Density Gradient Cytoplasm / metabolism Cytosol / metabolism Estrogens / metabolism* Female Humans Ovarian Neoplasms / metabolism* Receptors, Androgen / metabolism Receptors, Estrogen / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Androgens; 0/Estrogens; 0/Receptors, Androgen; 0/Receptors, Estrogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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