| Androgen induction of follicular epithelial cell growth is mediated via insulin-like growth factor-I from dermal papilla cells. | |
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MedLine Citation:
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PMID: 7626139 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Androgen significantly stimulates the proliferation of outer root sheath cells that are cocultured with beard dermal papilla cells without cell contact. The expression of insulin-like growth factor I (IGF-I) mRNA in beard dermal papilla cells was stimulated by androgen and antagonized by cyproterone acetate. Outer root sheath cells did not express mRNA for IGF-I either in the presence or absence of androgen. Both of these two types of cells expressed mRNA for IGF-I receptor and the expression was not affected by androgen. Neutralizing antibody against IGF-I antagonized the stimulatory effect of androgen on the growth of outer root sheath cell cocultured with beard dermal papilla cells. These findings suggest that IGF-I is a candidate for androgen induced hair growth factors. |
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Authors:
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S Itami; S Kurata; S Takayasu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 212 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1995 Jul |
Date Detail:
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Created Date: 1995-08-25 Completed Date: 1995-08-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 988-94 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Oita Medical University, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies Base Sequence Cell Division / drug effects Cells, Cultured Cyproterone Acetate / pharmacology DNA Primers / genetics Epithelial Cells Epithelium / drug effects, metabolism Hair / cytology, drug effects*, metabolism* Humans Insulin-Like Growth Factor I / antagonists & inhibitors, genetics, metabolism* Metribolone / pharmacology* Molecular Sequence Data Polymerase Chain Reaction RNA, Messenger / genetics, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; 0/DNA Primers; 0/RNA, Messenger; 427-51-0/Cyproterone Acetate; 67763-96-6/Insulin-Like Growth Factor I; 965-93-5/Metribolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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