Document Detail

Androgen induction of follicular epithelial cell growth is mediated via insulin-like growth factor-I from dermal papilla cells.
MedLine Citation:
PMID:  7626139     Owner:  NLM     Status:  MEDLINE    
Androgen significantly stimulates the proliferation of outer root sheath cells that are cocultured with beard dermal papilla cells without cell contact. The expression of insulin-like growth factor I (IGF-I) mRNA in beard dermal papilla cells was stimulated by androgen and antagonized by cyproterone acetate. Outer root sheath cells did not express mRNA for IGF-I either in the presence or absence of androgen. Both of these two types of cells expressed mRNA for IGF-I receptor and the expression was not affected by androgen. Neutralizing antibody against IGF-I antagonized the stimulatory effect of androgen on the growth of outer root sheath cell cocultured with beard dermal papilla cells. These findings suggest that IGF-I is a candidate for androgen induced hair growth factors.
S Itami; S Kurata; S Takayasu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  212     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1995-08-25     Completed Date:  1995-08-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  988-94     Citation Subset:  IM    
Department of Dermatology, Oita Medical University, Japan.
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MeSH Terms
Base Sequence
Cell Division / drug effects
Cells, Cultured
Cyproterone Acetate / pharmacology
DNA Primers / genetics
Epithelial Cells
Epithelium / drug effects,  metabolism
Hair / cytology,  drug effects*,  metabolism*
Insulin-Like Growth Factor I / antagonists & inhibitors,  genetics,  metabolism*
Metribolone / pharmacology*
Molecular Sequence Data
Polymerase Chain Reaction
RNA, Messenger / genetics,  metabolism
Reg. No./Substance:
0/Antibodies; 0/DNA Primers; 0/RNA, Messenger; 427-51-0/Cyproterone Acetate; 67763-96-6/Insulin-Like Growth Factor I; 965-93-5/Metribolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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