Document Detail

Androgen and glucocorticoid mechanisms in exercise-induced cardiac hypertrophy.
MedLine Citation:
PMID:  6234810     Owner:  NLM     Status:  MEDLINE    
Female rats were trained daily by means of two 2-h-long bouts of swimming separated by a 30- to 40-min rest period. Absolute ventricular weights of the swimmers were increased above sedentary control values by 6% after 2 days, 15% after 7 days, and 30% after 35 days of exercise. Resting levels of total and free serum testosterone and total 5 alpha-dihydrotestosterone were not altered by the training. Total serum corticosterone concentrations at rest were significantly lower in the 7-day (149 +/- 16 ng/ml) and 35-day (169 +/- 24) swimmers compared with the controls (293 +/- 26). However, free corticosterone was not significantly reduced from controls in any of the swimming groups. Ventricular muscle cytosol androgen receptor binding dissociation constants and receptor binding capacities, measured using [3H]methyltrienolone (R1881), were not significantly different from control values in the exercised groups. Glucocorticoid cytosol receptor binding capacity in ventricular tissue, determined using [3H]dexamethasone, was significantly increased as femtomoles per milligram protein (39.3 +/- 3.1 vs. 31.4 +/- 1.4) and femtomoles per milligram DNA (2,683 +/- 226 vs. 1,786 +/- 71). These findings show that glucocorticoids, rather than androgens, undergo adaptive changes in the circulation and in muscle during the development of exercise-induced cardiac hypertrophy.
R C Hickson; T M Galassi; T T Kurowski; D G Daniels; R T Chatterton
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  246     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1984 Jun 
Date Detail:
Created Date:  1984-07-31     Completed Date:  1984-07-31     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H761-7     Citation Subset:  IM    
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MeSH Terms
Androgens / metabolism*
Cardiomegaly / etiology,  physiopathology*
Glucocorticoids / metabolism*
Heart Ventricles / physiopathology
Organ Size
Physical Exertion*
Rats, Inbred Strains
Receptors, Androgen / metabolism
Receptors, Glucocorticoid / metabolism
Tritium / diagnostic use
Grant Support
Reg. No./Substance:
0/Androgens; 0/Glucocorticoids; 0/Receptors, Androgen; 0/Receptors, Glucocorticoid; 10028-17-8/Tritium

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