| Androgen and glucocorticoid mechanisms in exercise-induced cardiac hypertrophy. | |
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MedLine Citation:
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PMID: 6234810 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Female rats were trained daily by means of two 2-h-long bouts of swimming separated by a 30- to 40-min rest period. Absolute ventricular weights of the swimmers were increased above sedentary control values by 6% after 2 days, 15% after 7 days, and 30% after 35 days of exercise. Resting levels of total and free serum testosterone and total 5 alpha-dihydrotestosterone were not altered by the training. Total serum corticosterone concentrations at rest were significantly lower in the 7-day (149 +/- 16 ng/ml) and 35-day (169 +/- 24) swimmers compared with the controls (293 +/- 26). However, free corticosterone was not significantly reduced from controls in any of the swimming groups. Ventricular muscle cytosol androgen receptor binding dissociation constants and receptor binding capacities, measured using [3H]methyltrienolone (R1881), were not significantly different from control values in the exercised groups. Glucocorticoid cytosol receptor binding capacity in ventricular tissue, determined using [3H]dexamethasone, was significantly increased as femtomoles per milligram protein (39.3 +/- 3.1 vs. 31.4 +/- 1.4) and femtomoles per milligram DNA (2,683 +/- 226 vs. 1,786 +/- 71). These findings show that glucocorticoids, rather than androgens, undergo adaptive changes in the circulation and in muscle during the development of exercise-induced cardiac hypertrophy. |
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Authors:
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R C Hickson; T M Galassi; T T Kurowski; D G Daniels; R T Chatterton |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 246 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1984 Jun |
Date Detail:
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Created Date: 1984-07-31 Completed Date: 1984-07-31 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: H761-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Androgens
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metabolism* Animals Cardiomegaly / etiology, physiopathology* Female Glucocorticoids / metabolism* Heart Ventricles / physiopathology Organ Size Physical Exertion* Rats Rats, Inbred Strains Receptors, Androgen / metabolism Receptors, Glucocorticoid / metabolism Swimming Tritium / diagnostic use |
| Grant Support | |
ID/Acronym/Agency:
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AM-26408/AM/NIADDK NIH HHS; K04-AM-01100/AM/NIADDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Androgens; 0/Glucocorticoids; 0/Receptors, Androgen; 0/Receptors, Glucocorticoid; 10028-17-8/Tritium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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