Document Detail

Androgen excess down-regulates connexin43 in a human granulosa cell line.
MedLine Citation:
PMID:  20684953     Owner:  NLM     Status:  MEDLINE    
By use of a cell model, we found that high levels of androgen reduce connexin43 expression and impair gap junction intercellular communication between human granulosa cells through the androgen receptors. High levels of androgen may impair folliculogenesis and in turn lead to ovulatory dysfunction in polycystic ovary syndrome patients.
Cheng-Hsuan Wu; Jyuer-Ger Yang; Jiann-Jou Yang; Yueh-Min Lin; Hong-Der Tsai; Ching-Yuang Lin; Pao-Lin Kuo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-08-04
Journal Detail:
Title:  Fertility and sterility     Volume:  94     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-26     Completed Date:  2011-01-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2938-41     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Department of Obstetrics and Gynecology, Changhua Christian Hospital, Changhua, Taiwan.
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MeSH Terms
8-Bromo Cyclic Adenosine Monophosphate / pharmacology
Androgens / pharmacology*
Cell Line
Connexin 43 / metabolism*
Dose-Response Relationship, Drug
Down-Regulation / drug effects
Granulosa Cells / drug effects*,  metabolism
Ovarian Follicle / drug effects,  metabolism,  physiology
Polycystic Ovary Syndrome / etiology,  metabolism
Testosterone / analogs & derivatives,  pharmacology
Reg. No./Substance:
0/Androgens; 0/Connexin 43; 0/GJA1 protein, human; 23583-48-4/8-Bromo Cyclic Adenosine Monophosphate; 58-22-0/Testosterone; 846-48-0/dehydrotestosterone

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