| Androgen excess down-regulates connexin43 in a human granulosa cell line. | |
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MedLine Citation:
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PMID: 20684953 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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By use of a cell model, we found that high levels of androgen reduce connexin43 expression and impair gap junction intercellular communication between human granulosa cells through the androgen receptors. High levels of androgen may impair folliculogenesis and in turn lead to ovulatory dysfunction in polycystic ovary syndrome patients. |
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Authors:
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Cheng-Hsuan Wu; Jyuer-Ger Yang; Jiann-Jou Yang; Yueh-Min Lin; Hong-Der Tsai; Ching-Yuang Lin; Pao-Lin Kuo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-04 |
Journal Detail:
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Title: Fertility and sterility Volume: 94 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-26 Completed Date: 2011-01-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 2938-41 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Obstetrics and Gynecology, Changhua Christian Hospital, Changhua, Taiwan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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8-Bromo Cyclic Adenosine Monophosphate
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pharmacology Androgens / pharmacology* Cell Line Connexin 43 / metabolism* Dose-Response Relationship, Drug Down-Regulation / drug effects Female Granulosa Cells / drug effects*, metabolism Humans Ovarian Follicle / drug effects, metabolism, physiology Polycystic Ovary Syndrome / etiology, metabolism Testosterone / analogs & derivatives, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Androgens; 0/Connexin 43; 0/GJA1 protein, human; 23583-48-4/8-Bromo Cyclic Adenosine Monophosphate; 58-22-0/Testosterone; 846-48-0/dehydrotestosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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