Document Detail

Androgen deprivation therapy and cardiac function: effects of endurance training.
MedLine Citation:
PMID:  16786038     Owner:  NLM     Status:  MEDLINE    
PURPOSE: This study examined the effects of an 8-week androgen deprivation therapy treatment using Zoladex and an endurance training regimen on cardiac function. METHODS: Male Sprague-Dawley rats received either Zoladex or placebo. Animals remained sedentary or endurance trained during the drug treatment period. On day 57, ex vivo cardiac function was analyzed. RESULTS: Hearts from sedentary animals receiving Zoladex possessed significant cardiac dysfunction. However, hearts from exercise trained rats receiving Zoladex possessed cardiac function values similar to those from hearts from placebo animals. CONCLUSIONS: An 8-week treatment with Zoladex promoted cardiac dysfunction. Endurance training during Zoladex treatment protected against this cardiac dysfunction.
D S Hydock; K Y Wonders; C M Schneider; R Hayward
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-06-20
Journal Detail:
Title:  Prostate cancer and prostatic diseases     Volume:  9     ISSN:  1365-7852     ISO Abbreviation:  Prostate Cancer Prostatic Dis.     Publication Date:  2006  
Date Detail:
Created Date:  2006-11-30     Completed Date:  2007-07-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9815755     Medline TA:  Prostate Cancer Prostatic Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  392-8     Citation Subset:  IM    
School of Sport and Exercise Science and the Rocky Mountain Cancer Rehabilitation Institute, University of Northern Colorado, Greeley, CO, USA.
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MeSH Terms
Analysis of Variance
Antineoplastic Agents, Hormonal / pharmacology*
Biological Markers / blood
Coronary Circulation / drug effects*
Diastole / drug effects
Exercise Test
Goserelin / pharmacology
Heart / anatomy & histology
Heart Ventricles / drug effects,  metabolism,  physiopathology
Myosin Heavy Chains / biosynthesis,  drug effects
Organ Size
Physical Endurance / drug effects*
Rats, Sprague-Dawley
Systole / drug effects
Testis / anatomy & histology
Testosterone / blood
Ventricular Pressure / drug effects*
Reg. No./Substance:
0/Antineoplastic Agents, Hormonal; 0/Biological Markers; 0/Myosin Heavy Chains; 58-22-0/Testosterone; 65807-02-5/Goserelin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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