Document Detail

Androgen deprivation in males is associated with decreased central arterial compliance and reduced central systolic blood pressure.
MedLine Citation:
PMID:  10878703     Owner:  NLM     Status:  MEDLINE    
The higher incidence of coronary artery disease in men is often attributed to androgens. Arterial compliance or 'stiffness' is increasingly regarded as a modifiable risk factor for cardiovascular disease. We wanted to look at the effects of complete androgen withdrawal, on arterial compliance in men. We performed arterial compliance studies on 12 men with complete androgen deprivation as treatment for prostate cancer, and on 12 age-matched healthy controls. Central pulse wave velocities were significantly higher in the androgen-deprived men (14.2 +/- 2.7 vs 11.8 +/- 1.6 m/sec, P = 0. 02). The cases tended to have higher brachial systolic pressures than controls though this difference was not significant (P = 0.2). We conclude that androgen withdrawal is associated with a reduction in central arterial compliance. Conversely androgen withdrawal does not affect peripheral arterial compliance. It is unlikely that the presence of normal concentrations of androgens can explain the sex difference in mortality rates. Longitudinal studies are needed for further evaluation. Journal of Human Hypertension (2000) 14, 395-397
F Dockery; C Rajkumar; S Agarwal; J Waxman; C J Bulpitt
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of human hypertension     Volume:  14     ISSN:  0950-9240     ISO Abbreviation:  J Hum Hypertens     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-08-23     Completed Date:  2000-08-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8811625     Medline TA:  J Hum Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  395-7     Citation Subset:  IM    
Division of Medicine, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0HS, UK.
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MeSH Terms
Androgens / deficiency*
Arteries / physiopathology*
Blood Pressure Determination
Cardiovascular Diseases / epidemiology,  etiology*
Constriction, Pathologic
Cross-Sectional Studies
Multivariate Analysis
Risk Factors
Vascular Resistance*
Reg. No./Substance:

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