Document Detail

Androgen deprivation by flutamide modulates uPAR, MMP-9 expressions, lipid profile, and oxidative stress: amelioration by daidzein.
MedLine Citation:
PMID:  23135684     Owner:  NLM     Status:  Publisher    
The growth and development of prostate gland is governed by testosterone. Testosterone helps in maintaining the adipose tissue stores of the body. It is well documented that with advancing age there has been a gradual decline in testosterone levels. Our aim was to study the protective role of daidzein on flutamide-induced androgen deprivation on matrix degrading genes, lipid profile and oxidative stress in Wistar rats. Sub-chronic (60 days) flutamide (30 mg/kg b.wt) administration resulted in marked increase in expressions of matrix degrading genes [matrix metalloproteases 9 and urokinase plasminogen activation receptor]. Additionally, it increased the levels of low density lipoproteins, total cholesterol, triglycerides, and lowered the levels of high density lipoproteins and endogenous antioxidant levels. Oral administration of daidzein (20 and 60 mg/kg b.wt) restituted the levels to normal. Daidzein administration resulted in amelioration of the prostate atrophy, degeneracy and invasiveness induced by flutamide. Our findings suggest that the daidzein may be given as dietary supplement to patients who are on androgen deprivation therapy, to minimize the adverse effects related to it and also retarding susceptibility of patients to cardiovascular diseases.
Abdul Lateef; Abdul Quaiyoom Khan; Mir Tahir; Rehan Khan; Muneeb U Rehman; Farrah Ali; Oday O Hamiza; Sarwat Sultana
Related Documents :
22119864 - Avoidance behaviour and anxiety in rats irradiated with a sublethal dose of gamma-rays.
6253004 - The value of polymixin b in endotoxaemia due to experimental obstructive jaundice and m...
17496074 - Exercise pretraining protects against cerebral ischaemia induced by heat stroke in rats.
16138774 - A comparison of target-controlled infusion versus volatile inhalant anesthesia for hear...
22119394 - Cerebroprotective effects of tak-937, a cannabinoid receptor agonist, on ischemic brain...
2906864 - Influence of age on effects induced by intermittent ethanol treatment on the ethanol dr...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-8
Journal Detail:
Title:  Molecular and cellular biochemistry     Volume:  -     ISSN:  1573-4919     ISO Abbreviation:  Mol. Cell. Biochem.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0364456     Medline TA:  Mol Cell Biochem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Molecular Carcinogenesis and Chemoprevention Division, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi, 110 062, India.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Vaspin gene in rat adipose tissue: relation to obesity-induced insulin resistance.
Next Document:  Hematopoietic stem cell transplantation: a review and recommendations for follow-up care for the gen...