| Androgen deficiency and atherosclerosis: The lipid link. | |
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MedLine Citation:
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PMID: 19818414 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The relationship between androgen deficiency and atherosclerosis is complex, poorly understood, and remains controversial. The aim of this review is to evaluate the data in the literature to determine if androgen deficiency modulates lipid profiles and contributes to atherosclerosis development or progression. Studies in animals and humans suggest that androgen deficiency is associated with increased triglycerides (TGs), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C). Although the effects of androgen deficiency on high-density lipoprotein cholesterol (HDL-C) remains controversial, recent data suggest that androgen therapy is associated with increased levels of HDL-C and may improve reverse cholesterol transport. Animal studies suggested that androgen deprivation adversely affect lipid profiles and this was reversed by androgen treatment. Furthermore, androgen treatment of hypogonadal men significantly improved lipid profiles. Emerging data indicate that androgens play an important role in lipid metabolism. Therefore androgens are critical in the prevention and progression of atherosclerosis. Androgen deficiency contributes to increased TGs, TC, LDL-C and reduced HDL-C while androgen treatment results in a favorable lipid profile, suggesting that androgens may provide a protective effect against the development and/or progression of atherosclerosis. |
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Authors:
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Abdulmaged M Traish; Rami Abdou; Kyriakos E Kypreos |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2009-10-06 |
Journal Detail:
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Title: Vascular pharmacology Volume: 51 ISSN: 1879-3649 ISO Abbreviation: Vascul. Pharmacol. Publication Date: 2009 Nov-Dec |
Date Detail:
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Created Date: 2009-11-16 Completed Date: 2010-01-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101130615 Medline TA: Vascul Pharmacol Country: United States |
Other Details:
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Languages: eng Pagination: 303-13 Citation Subset: IM |
Affiliation:
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Department of Biochemistry and Urology, Boston University School of Medicine, Boston, MA 02118, USA. atraish@bu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Androgen Antagonists
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adverse effects Androgens / deficiency* Animals Apolipoproteins E / deficiency Atherosclerosis / epidemiology, etiology* Cholesterol, HDL / blood Humans Lipoproteins / metabolism Male Prostatic Neoplasms / drug therapy Testosterone / blood |
| Chemical | |
Reg. No./Substance:
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0/Androgen Antagonists; 0/Androgens; 0/Apolipoproteins E; 0/Cholesterol, HDL; 0/Lipoproteins; 58-22-0/Testosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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