Document Detail

Andersen-Tawil Syndrome Associated with Aborted Sudden Cardiac Death: Atrial Pacing Was Effective for Ventricular Arrhythmias.
MedLine Citation:
PMID:  22739561     Owner:  NLM     Status:  Publisher    
ABSTRACT:: A 37-year-old Japanese woman experienced aborted sudden cardiac death from ventricular fibrillation and was diagnosed with Andersen-Tawil syndrome by genetic analysis that revealed 2 mutations in the KCNJ2 gene. Although she received an implantation of implantable cardioverter defibrillator and beta-blocker therapy, the frequency of premature ventricular contraction and bidirectional ventricular tachycardia did not decrease. Her ventricular arrhythmias increased after a full stomach test and a neostigmine provocation test, and reduced after cibenzoline administration, which indicates the relation with vagal tone. Moreover, increasing the pacing rate significantly decreased them. These findings indicate that the arrhythmia was bradycardia-dependent in this case.
Yuki Kuramoto; Yoshio Furukawa; Takahisa Yamada; Yuji Okuyama; Masatake Fukunami
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-26
Journal Detail:
Title:  The American journal of the medical sciences     Volume:  -     ISSN:  1538-2990     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370506     Medline TA:  Am J Med Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Division of Cardiology (YK, YF, TY, MF), Osaka General Medical Center, Osaka, Japan; and Department of Advanced Cardiovascular Therapeutics (YO), Graduate School of Medicine, Osaka University, Osaka, Japan.
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