| The Andalusian population from Huelva reveals a high diversification of Y-DNA paternal lineages from haplogroup E: Identifying human male movements within the Mediterranean space. | |
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MedLine Citation:
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PMID: 19939195 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Gene flow among human populations is generally interpreted in terms of complex patterns, with the observed gene frequencies being the consequence of the entire genetic and demographic histories of the population. AIMS: This study performs a high-resolution analysis of the Y-chromosome haplogroup E in Western Andalusians (Huelva province). The genetic information presented here provides new insights into migration processes that took place throughout the Mediterranean space and tries to evaluate its impact on the current genetic composition of the most southwestern population of Spain. SUBJECTS AND METHODS: 167 unrelated males were previously typed for the presence/absence of the Y-chromosome Alu polymorphism (YAP). The group of YAP (+) Andalusians was genotyped for 16 Y-SNPs and also characterized for 16 Y-STR loci. Results: The distribution of E-M81 haplogroup, a Berber marker, was found at a frequency of 3% in our sample. The distribution of M81 frequencies in Iberia seems to be not concordant with the regions where Islamic rule was most intense and long-lasting. The study also showed that most of M78 derived allele (6.6%) led to the V13* subhaplogroup. We also found the most basal and rare paragroup M78* and others with V12 and V65 mutations. The lineage defined by M34 mutation, which is quite frequent in Jews, was detected as well. CONCLUSIONS: The haplogroup E among Western Andalusians revealed a complex admixture of genetic markers from the Mediterranean space, with interesting signatures of populations from the Middle East and the Balkan Peninsula and a surprisingly low influence by Berber populations compared to other areas of the Iberian Peninsula. |
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Authors:
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B Ambrosio; J M Dugoujon; C Hern?ndez; D De La Fuente; A Gonz?lez-Mart?n; C A Fortes-Lima; A Novelletto; J N Rodr?guez; Rosario Calder?n |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of human biology Volume: 37 ISSN: 1464-5033 ISO Abbreviation: Ann. Hum. Biol. Publication Date: 2010 Jan-Feb |
Date Detail:
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Created Date: 2009-12-08 Completed Date: 2010-02-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0404024 Medline TA: Ann Hum Biol Country: England |
Other Details:
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Languages: eng Pagination: 86-107 Citation Subset: IM |
Affiliation:
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Departamento de Zoolog?a y Antropolog?a F?sica, Facultad de Biolog?a, Universidad Complutense, Ciudad Universitaria, Madrid 28040, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Chromosomes, Human, Y
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genetics* Genetic Markers Genetics, Population* Haplotypes* Humans Male Polymorphism, Single Nucleotide Spain / ethnology |
| Chemical | |
Reg. No./Substance:
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0/Genetic Markers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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