Document Detail


Ancient admixture in human history.
MedLine Citation:
PMID:  22960212     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Population mixture is an important process in biology. We present a suite of methods for learning about population mixtures, implemented in a software package called ADMIXTOOLS, that support formal tests for whether mixture occurred and make it possible to infer proportions and dates of mixture. We also describe the development of a new single nucleotide polymorphism (SNP) array consisting of 629,433 sites with clearly documented ascertainment that was specifically designed for population genetic analyses and that we genotyped in 934 individuals from 53 diverse populations. To illustrate the methods, we give a number of examples that provide new insights about the history of human admixture. The most striking finding is a clear signal of admixture into northern Europe, with one ancestral population related to present-day Basques and Sardinians and the other related to present-day populations of northeast Asia and the Americas. This likely reflects a history of admixture between Neolithic migrants and the indigenous Mesolithic population of Europe, consistent with recent analyses of ancient bones from Sweden and the sequencing of the genome of the Tyrolean "Iceman."
Authors:
Nick Patterson; Priya Moorjani; Yontao Luo; Swapan Mallick; Nadin Rohland; Yiping Zhan; Teri Genschoreck; Teresa Webster; David Reich
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-09-07
Journal Detail:
Title:  Genetics     Volume:  192     ISSN:  1943-2631     ISO Abbreviation:  Genetics     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-08     Completed Date:  2013-04-23     Revised Date:  2013-11-05    
Medline Journal Info:
Nlm Unique ID:  0374636     Medline TA:  Genetics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1065-93     Citation Subset:  IM    
Affiliation:
Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA. nickp@broadinstitute.org
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MeSH Terms
Descriptor/Qualifier:
Algorithms
Continental Population Groups / genetics
Ethnic Groups / genetics
Evolution, Molecular
Gene Flow
Genetics, Population*
Humans
Hybridization, Genetic*
Internet
Models, Genetic
Polymorphism, Single Nucleotide
Software
Grant Support
ID/Acronym/Agency:
GM100233/GM/NIGMS NIH HHS; R01 GM100233/GM/NIGMS NIH HHS
Comments/Corrections

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