Document Detail

Anchoring stem cells in the niche by cell adhesion molecules.
MedLine Citation:
PMID:  19421010     Owner:  NLM     Status:  MEDLINE    
Adult stem cells generally reside in supporting local micro environments or niches, and intimate stem cell and niche association is critical for their long-term maintenance and function. Recent studies in model organisms especially Drosophila have started to unveil the underlying mechanisms of stem anchorage in the niche at the molecular and cellular level. Two types of cell adhesion molecules are emerging as essential players: cadherin-mediated cell adhesion for keeping stem cells within stromal niches, whereas integrin-mediated cell adhesion for keeping stem cells within epidermal niches. Further understanding stem cell anchorage and release in coupling with environmental changes should provide further insights into homeostasis control in tissues that harbor stem cells.
Rongwen Xi
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2009-10-01
Journal Detail:
Title:  Cell adhesion & migration     Volume:  3     ISSN:  1933-6926     ISO Abbreviation:  Cell Adh Migr     Publication Date:    2009 Oct-Dec
Date Detail:
Created Date:  2009-12-01     Completed Date:  2010-03-05     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  101469464     Medline TA:  Cell Adh Migr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  396-401     Citation Subset:  IM    
National Institute of Biological Sciences, Beijing, China.
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MeSH Terms
Adult Stem Cells / cytology*,  physiology
Cell Adhesion / physiology
Cell Adhesion Molecules / physiology*
Stem Cell Niche / cytology*,  physiology
Reg. No./Substance:
0/Cell Adhesion Molecules

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