| Anchoring stem cells in the niche by cell adhesion molecules. | |
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MedLine Citation:
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PMID: 19421010 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Adult stem cells generally reside in supporting local micro environments or niches, and intimate stem cell and niche association is critical for their long-term maintenance and function. Recent studies in model organisms especially Drosophila have started to unveil the underlying mechanisms of stem anchorage in the niche at the molecular and cellular level. Two types of cell adhesion molecules are emerging as essential players: cadherin-mediated cell adhesion for keeping stem cells within stromal niches, whereas integrin-mediated cell adhesion for keeping stem cells within epidermal niches. Further understanding stem cell anchorage and release in coupling with environmental changes should provide further insights into homeostasis control in tissues that harbor stem cells. |
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Authors:
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Rongwen Xi |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2009-10-01 |
Journal Detail:
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Title: Cell adhesion & migration Volume: 3 ISSN: 1933-6926 ISO Abbreviation: Cell Adh Migr Publication Date: 2009 Oct-Dec |
Date Detail:
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Created Date: 2009-12-01 Completed Date: 2010-03-05 Revised Date: 2010-12-07 |
Medline Journal Info:
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Nlm Unique ID: 101469464 Medline TA: Cell Adh Migr Country: United States |
Other Details:
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Languages: eng Pagination: 396-401 Citation Subset: IM |
Affiliation:
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National Institute of Biological Sciences, Beijing, China. xirongwen@nibs.ac.cn |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Stem Cells
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cytology*,
physiology Animals Cell Adhesion / physiology Cell Adhesion Molecules / physiology* Humans Stem Cell Niche / cytology*, physiology |
| Chemical | |
Reg. No./Substance:
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0/Cell Adhesion Molecules |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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