Document Detail

Anchor cell invasion into the vulval epithelium in C. elegans.
MedLine Citation:
PMID:  12852849     Owner:  NLM     Status:  MEDLINE    
An understanding of cell-invasive behavior has been limited by the lack of in vivo models where this activity can be clearly visualized and manipulated. We show that a single cell in the Caenorhabditis elegans gonad, the anchor cell (AC), initiates uterine-vulval contact through a cell invasion event. Using genetic analysis, laser ablations, and cell-specific markers, we demonstrate that AC invasion is predominantly stimulated by the 1 degrees vulval lineage cells, which generate a diffusible signal that promotes AC invasive behavior toward these cells and further targets invasive processes between the two central 1 degrees vulval lineage cells. We also show that AC invasion is regulated by the AC response to this cue, as well as a vulval-independent mechanism that weakly drives invasion. These studies dissect the regulatory mechanisms that underlie a simple cell-invasive behavior in vivo, and introduce AC invasion as a model for understanding key checkpoints controlling cell invasion.
David R Sherwood; Paul W Sternberg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Developmental cell     Volume:  5     ISSN:  1534-5807     ISO Abbreviation:  Dev. Cell     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-07-10     Completed Date:  2003-09-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101120028     Medline TA:  Dev Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  21-31     Citation Subset:  IM    
Howard Hughes Medical Institute and Division of Biology, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA.
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MeSH Terms
Animals, Genetically Modified
Biological Markers
Cadherins / genetics,  metabolism
Caenorhabditis elegans / embryology*,  genetics
Caenorhabditis elegans Proteins / genetics,  metabolism
Cell Lineage
Cell Movement / genetics
Epithelium / embryology
Gene Expression Regulation, Developmental*
Gonads / cytology,  embryology
Green Fluorescent Proteins
Luminescent Proteins / metabolism
Signal Transduction
Uterus / cytology,  embryology
Vulva / cytology,  embryology
Reg. No./Substance:
0/Biological Markers; 0/Cadherins; 0/Caenorhabditis elegans Proteins; 0/Luminescent Proteins; 147336-22-9/Green Fluorescent Proteins
Comment In:
Dev Cell. 2003 Jul;5(1):5-7   [PMID:  12852846 ]

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