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Ancestral susceptibility to colorectal cancer.
MedLine Citation:
PMID:  22294767     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Every year, approximately 1 million new colorectal cancer (CRC) cases are diagnosed and about half a million people worldwide die due to this cancer. Known differences in CRC incidence rates are mainly attributed to differences in diet and other environmental factors represented, among others, by nutrition-related complex diseases (e.g. obesity and diabetes mellitus type II). Within the last years, it has become evident that environmental risk factors can be complemented by a genetic component when considering the risk of CRC. For example, a number of polymorphisms are known to be associated with an increased risk of obesity and obesity is a risk factor for CRC. Several studies have shown that the 'ancestral-susceptibility model' can be reasonably applied to nutrition-related complex diseases such as obesity. The work in hand shortly discusses whether the ancestral-susceptibility model can also be applied to CRC as a nutrition-related complex disease.
Authors:
Stefanie Huhn; Barbara Pardini; Alessio Naccarati; Pavel Vodicka; Kari Hemminki; Asta Försti
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Mutagenesis     Volume:  27     ISSN:  1464-3804     ISO Abbreviation:  Mutagenesis     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8707812     Medline TA:  Mutagenesis     Country:  England    
Other Details:
Languages:  eng     Pagination:  197-204     Citation Subset:  IM    
Affiliation:
Department of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69121 Heidelberg, Germany.
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