Document Detail


Ancestral susceptibility to colorectal cancer.
MedLine Citation:
PMID:  22294767     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Every year, approximately 1 million new colorectal cancer (CRC) cases are diagnosed and about half a million people worldwide die due to this cancer. Known differences in CRC incidence rates are mainly attributed to differences in diet and other environmental factors represented, among others, by nutrition-related complex diseases (e.g. obesity and diabetes mellitus type II). Within the last years, it has become evident that environmental risk factors can be complemented by a genetic component when considering the risk of CRC. For example, a number of polymorphisms are known to be associated with an increased risk of obesity and obesity is a risk factor for CRC. Several studies have shown that the 'ancestral-susceptibility model' can be reasonably applied to nutrition-related complex diseases such as obesity. The work in hand shortly discusses whether the ancestral-susceptibility model can also be applied to CRC as a nutrition-related complex disease.
Authors:
Stefanie Huhn; Barbara Pardini; Alessio Naccarati; Pavel Vodicka; Kari Hemminki; Asta Försti
Related Documents :
1498737 - Recent trends in the management of breast cancer. 3. controversies in the use of adjuva...
16135407 - Atypical hearing loss in women with breast cancer receiving adjuvant treatment.
21461167 - Epidemiology of cancer of the small intestine.
8971467 - Adjuvant systemic therapy for breast cancer.
1523367 - The status of psychosocial research in the rehabilitation of the cancer patient.
15637647 - Brain metastases.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Mutagenesis     Volume:  27     ISSN:  1464-3804     ISO Abbreviation:  Mutagenesis     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8707812     Medline TA:  Mutagenesis     Country:  England    
Other Details:
Languages:  eng     Pagination:  197-204     Citation Subset:  IM    
Affiliation:
Department of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69121 Heidelberg, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The role of ABC transporters in progression and clinical outcome of colorectal cancer.
Next Document:  Role of variations within microRNA-binding sites in cancer.