| Ancestral lipid biosynthesis and early membrane evolution. | |
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MedLine Citation:
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PMID: 15337120 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Archaea possess unique membrane phospholipids that generally comprise isoprenoid ethers built on sn-glycerol-1-phosphate (G1P). By contrast, bacterial and eukaryal membrane phospholipids are fatty acid esters linked to sn-glycerol-3-phosphate (G3P). The two key dehydrogenase enzymes that produce G1P and G3P, G1PDH and G3PDH, respectively, are not homologous. Various models propose that these enzymes originated during the speciation of the two prokaryotic domains, and the nature (and even the very existence) of lipid membranes in the last universal common ancestor (cenancestor) is subject to debate. G1PDH and G3PDH belong to two separate superfamilies that are universally distributed, suggesting that members of both superfamilies existed in the cenancestor. Furthermore, archaea possess homologues to known bacterial genes involved in fatty acid metabolism and synthesize fatty acid phospholipids. The cenancestor seems likely to have been endowed with membrane lipids whose synthesis was enzymatic but probably non-stereospecific. |
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Authors:
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Juli Peretó; Purificación López-García; David Moreira |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Trends in biochemical sciences Volume: 29 ISSN: 0968-0004 ISO Abbreviation: Trends Biochem. Sci. Publication Date: 2004 Sep |
Date Detail:
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Created Date: 2004-08-31 Completed Date: 2004-12-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7610674 Medline TA: Trends Biochem Sci Country: England |
Other Details:
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Languages: eng Pagination: 469-77 Citation Subset: IM |
Affiliation:
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Unité d'Ecologie, Systématique et Evolution, UMR CNRS 8079, Université Paris-Sud, 91405 Orsay Cedex, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Archaea
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classification,
genetics,
physiology Bacteria / classification, genetics Cell Membrane / physiology, ultrastructure Evolution, Molecular* Glyceraldehyde-3-Phosphate Dehydrogenases / genetics Glycerolphosphate Dehydrogenase / genetics Lipids / biosynthesis* Membrane Lipids / biosynthesis* Phospholipids / biosynthesis* Phylogeny |
| Chemical | |
Reg. No./Substance:
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0/Lipids; 0/Membrane Lipids; 0/Phospholipids; EC 1.1.-/Glycerolphosphate Dehydrogenase; EC 1.1.1.-/glycerol-1-phosphate dehydrogenase; EC 1.2.1.-/Glyceraldehyde-3-Phosphate Dehydrogenases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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