| Anatomy and electrophysiology of the human AV node. | |
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MedLine Citation:
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PMID: 20180918 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The atrioventricular node (AVN) has mystified generations of investigators over the last century and continues today to be at the epicenter of debates among anatomists, experimentalists, and electrophysiologists. Over the years, discrepancies have remained in regard to correlating components of AVN structure to function, as evidenced by studies from microelectrodes, optical mapping, and the electrophysiology laboratory. Historically, the AVN has been defined by classical histological methods; however, with recent advances in molecular biology techniques, a more precise characterization of structure is becoming attainable. Distinct molecular compartments are becoming apparent based on connexin staining and genotyping, providing new insight into previously characterized functional aspects of the AVN and its surrounding structures. Advances in optical mapping have provided a unique opportunity for correlating structure and function--unmasking properties of the native AVN pacemaker and providing further insight into basic mechanisms involved in AV conduction. Additionally, procurement of explanted human hearts have provided a unique opportunity to further characterize the human AVN structurally and functionally with both molecular biology techniques and optical mapping. With the elucidation of basic elements of both structure and function via molecular investigation and optical mapping, new opportunities are becoming apparent in utilizing the unique properties of the AVN for pursuing novel clinical applications relevant to clinical electrophysiology. |
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Authors:
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Thomas Kurian; Christina Ambrosi; William Hucker; Vadim V Fedorov; Igor R Efimov |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-02-18 |
Journal Detail:
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Title: Pacing and clinical electrophysiology : PACE Volume: 33 ISSN: 1540-8159 ISO Abbreviation: Pacing Clin Electrophysiol Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-07-13 Completed Date: 2010-11-02 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 7803944 Medline TA: Pacing Clin Electrophysiol Country: United States |
Other Details:
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Languages: eng Pagination: 754-62 Citation Subset: IM |
Affiliation:
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Washington University, St. Louis, Missouri 63130, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atrioventricular Node / anatomy & histology*, physiology* Humans Voltage-Sensitive Dye Imaging |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL085369-01A2/HL/NHLBI NIH HHS; R01 HL085369-02/HL/NHLBI NIH HHS; R01 HL085369-04/HL/NHLBI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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