Document Detail


Anatomy and Bronchoscopy of the Porcine Lung: A Model for Translational Respiratory Medicine.
MedLine Citation:
PMID:  24828366     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The porcine model has contributed significantly to biomedical research over many decades. The similar size and anatomy of pig and human organs make this model particularly beneficial for translational research in areas such as medical device development, therapeutics and xenotransplantation. In recent years, a major limitation with the porcine model was overcome with the successful generation of gene targeted pigs and the publication of the pig genome. As a result, the role of this model is likely to become even more important. For the respiratory medicine field, the similarities between pig and human lungs give the porcine model particular potential for advancing translational medicine. An increasing number of lung conditions are being studied and modelled in the pig. Notably, genetically modified porcine models of cystic fibrosis (CF) have been generated which, unlike mouse models, develop lung disease similar to human CF. However, the scientific literature relating specifically to porcine lung anatomy and airway histology is limited and is largely restricted to veterinary literature and text books. Furthermore, methods for in vivo lung procedures in the pig are rarely described. The aims of this review are as follows: firstly, to collate the disparate literature on porcine lung anatomy, histology and microbiology; secondly, to provide a comparison with the human lung and thirdly, to describe appropriate bronchoscopy procedures for the pig lungs to aid clinical researchers working in the area of translational respiratory medicine using the porcine model.
Authors:
Eoin P Judge; Jm Lynne Hughes; Jim J Egan; Michael Maguire; Emer L Molloy; Shirley O'Dea
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-5-14
Journal Detail:
Title:  American journal of respiratory cell and molecular biology     Volume:  -     ISSN:  1535-4989     ISO Abbreviation:  Am. J. Respir. Cell Mol. Biol.     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-5-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8917225     Medline TA:  Am J Respir Cell Mol Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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