| Anatomolecular imaging with 2-deoxy-2-[18F]fluoro-D-glucose: bench to outpatient center. | |
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MedLine Citation:
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PMID: 14499144 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Anatomic imaging of cancer using X-rays has proven very useful for more than a century but has clear limitations. Anatomic methods quite reliably show whether a large mass is present or absent, but not what the mass is composed of. Imaging additional phenotypic alterations of the altered genotype of cancers with positron emission tomography (PET)adds clinically valuable information for patient management. Although many molecular alterations are present in cancer, to date the one most exploited in practice has been the accelerated glucose metabolism present in most cancers. This process is well-imaged with the radiotracer 2-deoxy-2-[18F]fluoro-D-glucose, the most commonly used molecular imaging agent with PET. The ability to combine the molecular and anatomic imaging of the entire body into hybrid anatomolecular images using dedicated PET-CT devices very likely represents the future of cancer imaging. |
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Authors:
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Richard L Wahl |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging Volume: 5 ISSN: 1536-1632 ISO Abbreviation: Mol Imaging Biol Publication Date: 2003 Mar-Apr |
Date Detail:
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Created Date: 2003-09-22 Completed Date: 2004-06-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101125610 Medline TA: Mol Imaging Biol Country: United States |
Other Details:
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Languages: eng Pagination: 49-56 Citation Subset: IM |
Affiliation:
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Department of Nuclear Medicine, Johns Hopkins University, Baltimore, MD, USA. rwahl@jhmi.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biological Transport Fluorodeoxyglucose F18 / diagnostic use*, pharmacokinetics Glucose / metabolism Humans Neoplasms / metabolism, radionuclide imaging* Radiopharmaceuticals / diagnostic use*, pharmacokinetics Tomography, Emission-Computed / methods Tomography, Emission-Computed, Single-Photon / methods |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 50-99-7/Glucose; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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