| Anatomofunctional organization of the insular cortex: a study using intracerebral electrical stimulation in epileptic patients. | |
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MedLine Citation:
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PMID: 20946128 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Different lines of evidence suggest that the insular cortex has many important functional roles. Direct electrical stimulation (ES) of the human insular cortex during surgical procedures for epilepsy, functional imaging techniques, and lesion studies also occasionally induces clinical responses. METHODS: In this study, we evaluated 25 patients with drug-refractory focal epilepsy by stereotactically implanting at least one electrode into the insular cortex using an oblique approach (transfrontal or transparietal). One hundred twenty-eight insular sites (each situated between two contiguous contacts within the same electrode) were examined within the gyral substructures. We located each stimulation site by fusing preimplantation three-dimensional (3D) magnetic resonance imaging (MRI) images with the postimplantation 3D computed tomography (CT) scans that revealed the electrode contacts. RESULTS: Sixty-seven stimulations induced at least one clinical response. Stimulation from within the insular cortex evoked 83 responses, without evidence of afterdischarge in the insular or extrainsular regions. We classified the principal responses as sensory (paresthesias and localized warm sensations), motor, pain, auditory, oropharyngeal, speech disturbances (including speech arrest and reduced voice intensity) and neurovegetative phenomena, such as facial reddening, generalized sensations of warmth or cold, hypogastric sensations, anxiety attacks, respiratory accelerations, sensations of rotation, and nausea. CONCLUSIONS: These findings may indicate a functional specificity for the insular gyri and show the need for exploring this structure during invasive presurgical evaluation of epileptic patients according to seizure manifestations. |
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Authors:
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Afif Afif; Lorella Minotti; Philippe Kahane; Dominique Hoffmann |
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Publication Detail:
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Type: Journal Article Date: 2010-10-13 |
Journal Detail:
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Title: Epilepsia Volume: 51 ISSN: 1528-1167 ISO Abbreviation: Epilepsia Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-27 Completed Date: 2011-01-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2983306R Medline TA: Epilepsia Country: United States |
Other Details:
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Languages: eng Pagination: 2305-15 Citation Subset: IM |
Copyright Information:
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Wiley Periodicals, Inc. © 2010 International League Against Epilepsy. |
Affiliation:
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Department of Neurosurgery, Neurological Hospital, Hospices Civils de Lyon, Lyon, France. afif_acc@hotmail.com |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Brain Mapping / methods* Cerebral Cortex / pathology*, physiopathology* Child Deep Brain Stimulation* Dominance, Cerebral / physiology Epilepsies, Partial / pathology*, physiopathology* Epilepsy / etiology, pathology*, physiopathology* Female Humans Image Processing, Computer-Assisted* Imaging, Three-Dimensional* Magnetic Resonance Imaging* Male Middle Aged Stereotaxic Techniques Tomography, X-Ray Computed* Young Adult |
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