Document Detail


Anatomical structure and surface epithelial distribution in the nasal cavity of the common cotton-eared marmoset (Callithrix jacchus).
MedLine Citation:
PMID:  10067203     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To validate use of the common cotton-eared marmoset (Callithrix jacchus) in inhalation toxicity studies, its nasal morphology was examined. The nasal turbinates each consisted of one maxilloturbinate and one ethmoturbinate: these were more planar in structure than the comparable structures of rodents or dogs. The nasal cavity epithelia comprised squamous epithelium (SE), nasal transitional epithelium (NTE), respiratory epithelium (RE) and olfactory epithelium (OE), listed in order of occurrence from anterior to posterior positions. NTE was distributed as a narrow band lying between SE and RE. OE was limited to the dorsal part of the cavity, which was structurally similar to that of the macaque or man. Overall, this study revealed structural the similarity of the whole nasal cavity in the marmoset to that of macaques or humans. Prediction of nasal cavity changes in man based on extrapolation from experimentally induced changes in the common marmoset therefore seems likely to be feasible, making it a useful animal model for inhalation studies.
Authors:
K Wako; H Hiratsuka; O Katsuta; M Tsuchitani
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Experimental animals / Japanese Association for Laboratory Animal Science     Volume:  48     ISSN:  1341-1357     ISO Abbreviation:  Exp. Anim.     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-04-27     Completed Date:  1999-04-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9604830     Medline TA:  Exp Anim     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  31-6     Citation Subset:  IM    
Affiliation:
Mitsubishi Chemical Safety Institute Ltd., Ibaraki, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Callithrix
Dogs
Humans
Macaca
Nasal Cavity / anatomy & histology*,  cytology
Nasal Mucosa / anatomy & histology*,  cytology
Species Specificity
Turbinates / anatomy & histology*

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