Document Detail

Anatomical position of hyaluronic Acid gel following injection to the infraorbital hollows.
MedLine Citation:
PMID:  23299806     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To examine with histology the anatomical location of hyaluronic acid gel injected to the infraorbital hollows of cadaver specimens.
METHODS: The authors dissected 5 fresh hemifacial cadaver specimens following preperiosteal injection of hyaluronic acid gel to the infraorbital hollows. Following tissue fixation, full-thickness soft tissue sections were obtained along the medial, central, and lateral lower eyelid/midface of each specimen. Histologic examination of the anatomical location of hyaluronic acid gel was performed using hematoxylin and eosin and Hale colloidal iron stains.
RESULTS: Histologic examination of the central and lateral lower eyelid/midface sections revealed a significant portion of hyaluronic acid gel in either a postorbicularis or a subcutaneous plane in 8 of 10 sections. Only 2 sections displayed hyaluronic acid gel solely within a preperiosteal plane. The medial sections revealed hyaluronic acid gel resting in either a preperiosteal or an intraorbicularis plane. Soft tissue structures such as deep fat compartment septa and the orbicularis oculi muscle appeared to play a significant role in influencing the resting position of hyaluronic acid gel.
CONCLUSIONS: In most specimens, the location of a significant portion of hyaluronic acid gel following injection to the infraorbital hollows differed from the intended injection plane. Soft tissue structures including fat compartment septa and the orbicularis oculi muscle appear to influence the resting position of hyaluronic acid gel. Careful attention should be used to avoid overfilling the thin soft tissue layers of the medial infraorbital hollows or tear trough.
Gregory J Griepentrog; Bradley N Lemke; Cat N Burkat; John G Rose; Mark J Lucarelli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ophthalmic plastic and reconstructive surgery     Volume:  29     ISSN:  1537-2677     ISO Abbreviation:  Ophthal Plast Reconstr Surg     Publication Date:    2013 Jan-Feb
Date Detail:
Created Date:  2013-01-09     Completed Date:  2013-06-20     Revised Date:  2014-01-08    
Medline Journal Info:
Nlm Unique ID:  8508431     Medline TA:  Ophthal Plast Reconstr Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  35-9     Citation Subset:  IM    
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MeSH Terms
Biocompatible Materials / administration & dosage
Cosmetic Techniques*
Eyelids / drug effects*,  pathology
Facial Muscles / drug effects,  pathology
Hyaluronic Acid / administration & dosage*
Injections, Intradermal
Oculomotor Muscles / drug effects,  pathology
Orbit / drug effects*,  pathology
Skin Aging
Viscosupplements / administration & dosage*
Reg. No./Substance:
0/Biocompatible Materials; 0/Juvederm Ultra; 0/Viscosupplements; 9004-61-9/Hyaluronic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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