Document Detail


Anatomical pitfalls during encircling cryoablation of the left atrium for atrial fibrillation therapy in the pig.
MedLine Citation:
PMID:  18324459     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We previously published encircling endocardial cryo-isolation of the pulmonary vein (PV) region. This study documented mechanisms of isolation failure using CARTO mapping. Cryo-isolation used a modified Surgifrost introduced via a Universal Cardiac Introducer on the left atrial appendage. Of five pigs, two had incomplete isolation and repeat mapping: Activation was over Bachmann's bundle (BB) in one and the coronary sinus (CS) in the other. Repeat cryoablation failed to eliminate gaps. Histologically, the BB gap had nonlesioned sub-epicardial fibres and thick fat covering the cryolesioned BB: fat protecting the epicardium from cryoablation. The inferior gap had a large CS, and a thick myocardium bridging the isthmus: myocardial thickness and CS thermal sink preventing transmural cryolesions. CARTO mapping localized gaps. Although the CS is known to cause failure, its protective mechanism is not well documented. The BB gap is novel. These findings have important clinical implications for isolation of the PV region.
Authors:
Douglas L Jones; Gerard M Guiraudon; Allan C Skanes; Colette M Guiraudon
Related Documents :
7628129 - Clinical applications of body surface potential mapping.
19026819 - Surgical ablation for atrial fibrillation: the efficacy of a novel bipolar pen device i...
14559439 - Safety of radiofrequency ablation of myocardium and lung adjacent to the heart: an anim...
11342759 - Echocardiographic transponder-guided catheter ablation feasibility and accuracy.
15548889 - Radiofrequency catheter ablation of idiopathic left ventricular tachycardia originating...
12679939 - Experimental study on the feasibility and safety of radiofrequency ablation for seconda...
21766239 - Comparison of the temporal release pattern of copeptin with conventional biomarkers in ...
3257839 - Improved survival up to four years after early coronary thrombolysis.
6168859 - Electrophysiologic and antiarrhythmic effects of nitroglycerin in man.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-03-07
Journal Detail:
Title:  Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing     Volume:  21     ISSN:  1383-875X     ISO Abbreviation:  J Interv Card Electrophysiol     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-08     Completed Date:  2008-09-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9708966     Medline TA:  J Interv Card Electrophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  187-93     Citation Subset:  IM    
Affiliation:
Department of Physiology and Pharmacology, The University of Western Ontario, London, Ontario, Canada, N6A 5C1. Doug.Jones@schulich.uwo.ca
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Atrial Fibrillation / surgery*
Catheter Ablation*
Coronary Artery Bypass, Off-Pump / methods
Cryosurgery / methods
Disease Models, Animal
Electrophysiologic Techniques, Cardiac / methods
Heart Atria / anatomy & histology*,  surgery
Pulmonary Veins / surgery*
Swine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Age and gender trends in implantable cardioverter defibrillator utilization: a population based stud...
Next Document:  Concepts of burden in giving care to older relatives: a study of female caregivers in a Mexico City ...