| Anatomical and histological changes in the oviducts of Japanese quail, Coturnix japonica, after embryonic exposure to ethynyloestradiol. | |
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MedLine Citation:
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PMID: 11226039 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Oestrogen is needed for normal oviductal development in female birds, but excessive early exposure to oestrogen can cause oviductal abnormalities and impair egg-laying ability. In this study, the anatomical and histological effects of in ovo exposure to the synthetic oestrogen ethynyloestradiol on the oviducts of immature and adult female Japanese quail, Coturnix japonica, were investigated. A series of abnormalities was observed after injection of ethynyloestradiol (2 or 20 ng g(-1) egg) into the yolk on day 3 of incubation. Ethynyloestradiol induced precocious differentiation of the luminal epithelium and tubular glands in immature chicks. Right-side oviduct retention occurred at all the ages studied, whereas certain other effects were not evident until sexual maturity. The left oviduct was reduced in size and tubular gland density in the uterus (shell gland) was reduced in sexually mature birds that had been treated with ethynyloestradiol. The utero-vaginal junction was longer than in control birds and had a higher tubular gland density. The epithelial cells in the magnum were taller in birds treated with ethynyloestradiol. Embryonic exposure to the environmental contaminant ethynyloestradiol may cause persisting structural malformations in oviducts of quails, which can impair fertility. As oviductal malformations are indicative of embryonic exposure to exogenous oestrogen, they are potentially useful as biomarkers of xenooestrogen exposure in wild bird populations. |
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Authors:
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C Berg; L Holm; I Brandt; B Brunström |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Reproduction (Cambridge, England) Volume: 121 ISSN: 1470-1626 ISO Abbreviation: Reproduction Publication Date: 2001 Jan |
Date Detail:
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Created Date: 2001-08-28 Completed Date: 2001-09-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100966036 Medline TA: Reproduction Country: England |
Other Details:
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Languages: eng Pagination: 155-65 Citation Subset: IM |
Affiliation:
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Department of Environmental Toxicology, Centre for Reproductive Biology in Uppsala, Uppsala University, Norbyvägen 18 A, SE-752 36 Uppsala, Sweden. cecilia.berg@etox.uu.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging Animals Cell Differentiation / drug effects Coturnix / embryology* Egg Yolk Epithelial Cells / cytology, drug effects Ethinyl Estradiol / administration & dosage, pharmacology* Female Injections Muscle, Smooth / anatomy & histology, drug effects Oviducts / anatomy & histology, drug effects, embryology* Uterus / anatomy & histology, drug effects |
| Chemical | |
Reg. No./Substance:
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57-63-6/Ethinyl Estradiol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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