Document Detail


Anatomical and histological changes in the oviducts of Japanese quail, Coturnix japonica, after embryonic exposure to ethynyloestradiol.
MedLine Citation:
PMID:  11226039     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Oestrogen is needed for normal oviductal development in female birds, but excessive early exposure to oestrogen can cause oviductal abnormalities and impair egg-laying ability. In this study, the anatomical and histological effects of in ovo exposure to the synthetic oestrogen ethynyloestradiol on the oviducts of immature and adult female Japanese quail, Coturnix japonica, were investigated. A series of abnormalities was observed after injection of ethynyloestradiol (2 or 20 ng g(-1) egg) into the yolk on day 3 of incubation. Ethynyloestradiol induced precocious differentiation of the luminal epithelium and tubular glands in immature chicks. Right-side oviduct retention occurred at all the ages studied, whereas certain other effects were not evident until sexual maturity. The left oviduct was reduced in size and tubular gland density in the uterus (shell gland) was reduced in sexually mature birds that had been treated with ethynyloestradiol. The utero-vaginal junction was longer than in control birds and had a higher tubular gland density. The epithelial cells in the magnum were taller in birds treated with ethynyloestradiol. Embryonic exposure to the environmental contaminant ethynyloestradiol may cause persisting structural malformations in oviducts of quails, which can impair fertility. As oviductal malformations are indicative of embryonic exposure to exogenous oestrogen, they are potentially useful as biomarkers of xenooestrogen exposure in wild bird populations.
Authors:
C Berg; L Holm; I Brandt; B Brunström
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Reproduction (Cambridge, England)     Volume:  121     ISSN:  1470-1626     ISO Abbreviation:  Reproduction     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-08-28     Completed Date:  2001-09-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100966036     Medline TA:  Reproduction     Country:  England    
Other Details:
Languages:  eng     Pagination:  155-65     Citation Subset:  IM    
Affiliation:
Department of Environmental Toxicology, Centre for Reproductive Biology in Uppsala, Uppsala University, Norbyvägen 18 A, SE-752 36 Uppsala, Sweden. cecilia.berg@etox.uu.se
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MeSH Terms
Descriptor/Qualifier:
Aging
Animals
Cell Differentiation / drug effects
Coturnix / embryology*
Egg Yolk
Epithelial Cells / cytology,  drug effects
Ethinyl Estradiol / administration & dosage,  pharmacology*
Female
Injections
Muscle, Smooth / anatomy & histology,  drug effects
Oviducts / anatomy & histology,  drug effects,  embryology*
Uterus / anatomy & histology,  drug effects
Chemical
Reg. No./Substance:
57-63-6/Ethinyl Estradiol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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