Document Detail

Anatomical factors triggering platypnea-orthodeoxia in adults.
MedLine Citation:
PMID:  19816867     Owner:  NLM     Status:  MEDLINE    
Right to left shunting through a patent foramen ovale (PFO) or atrial septal defect (ASD) can cause platypnea-orthodeoxia even in a setting of normal pulmonary artery pressures. However, the late onset of symptoms despite the congenital origin of the anatomical defects is not well understood. We report a case series of patients presenting with dyspnea and orthodeoxia who developed right to left shunting as a result of associated anatomical changes that occur with aging such as tortuosity and elongation of the aorta. We propose that these acquired anatomical changes can favor right to left shunting in the setting of congenital abnormalities, therefore explaining the late onset of symptoms.
Vijaya Sanikommu; David Lasorda; Indu Poornima
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical cardiology     Volume:  32     ISSN:  1932-8737     ISO Abbreviation:  Clin Cardiol     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-30     Completed Date:  2010-02-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7903272     Medline TA:  Clin Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E55-7     Citation Subset:  IM    
The Gerald McGinnis Cardiovascular Institute, Department of Medicine, Allegheny General Hospital, 320 East North Avenue, Pittsburgh, PA 15212 USA.
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MeSH Terms
Age Factors
Anoxia / etiology*,  pathology,  physiopathology
Aorta / pathology*,  physiopathology
Diaphragm / pathology*,  physiopathology
Dyspnea / etiology*,  pathology,  physiopathology
Echocardiography, Transesophageal
Foramen Ovale, Patent / complications*,  physiopathology,  ultrasonography
Heart Catheterization / instrumentation
Heart Septal Defects, Atrial / complications*,  physiopathology,  therapy,  ultrasonography
Magnetic Resonance Imaging
Paralysis / complications*,  pathology,  physiopathology
Risk Factors
Septal Occluder Device
Severity of Illness Index
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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