Document Detail


Anatomic and clinical correlates of septal morphology in hypertrophic cardiomyopathy.
MedLine Citation:
PMID:  21044981     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
METHODS AND RESULTS: Seventy-five consecutive adult patients with HCM were enrolled. Septal morphologies were retrospectively categorized into one of four patterns of hypertrophy based on transthoracic echocardiography. Left ventricular diastolic function by Doppler echocardiography and late gadolinium enhancement (LGE) by magnetic resonance imaging were assessed in all patients. Patients were followed for a mean of 45 ± 32 months. Catenoid septum was the most common morphologic subtype (46 of 75, 61%), followed by simple sigmoid (22 of 75, 29%), neutral (4 of 75, 5%), and apical (3 of 75, 4%). Inter-observer reproducibility of septal classifications was high (κ = 0.95). Patients with the catenoid subtype presented at a younger age, had worse diastolic function, and high rates of LGE. The presence of catenoid septal morphology was independently associated with LGE in multivariable logistic regression analysis. Implantable cardioverter-defibrillator implantation for prevention of sudden cardiac death occurred only in patients with this septal morphology.
CONCLUSION: We propose a simple, reproducible classification system of patterns of septal hypertrophy in HCM. These patterns of hypertrophy are associated with significant differences in clinical, haemodynamic, and myocardial characteristics. Further studies are needed to evaluate the relationship between septal morphology and outcome or response to therapies in HCM.
Authors:
Aslan T Turer; Zainab Samad; Anne Marie Valente; Michele A Parker; Brenda Hayes; Raymond J Kim; Joseph Kisslo; Andrew Wang
Publication Detail:
Type:  Journal Article     Date:  2010-11-01
Journal Detail:
Title:  European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology     Volume:  12     ISSN:  1532-2114     ISO Abbreviation:  Eur J Echocardiogr     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-10     Completed Date:  2011-06-09     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  100890618     Medline TA:  Eur J Echocardiogr     Country:  England    
Other Details:
Languages:  eng     Pagination:  131-9     Citation Subset:  IM    
Affiliation:
Division of Cardiology, Department of Medicine, University of Texas-Southwestern, 5323 Harry Hines Blvd, Dallas, TX 75390-9047, USA. aslan.turer@utsouthwestern.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Algorithms
Cardiomyopathy, Hypertrophic / classification,  pathology*,  ultrasonography
Echocardiography
Female
Gadolinium / diagnostic use*
Heart Septum / anatomy & histology,  pathology*,  ultrasonography
Heart Ventricles / pathology*,  ultrasonography
Hemodynamics
Humans
Magnetic Resonance Imaging, Cine
Male
Middle Aged
Multivariate Analysis
Reference Values
Retrospective Studies
Ventricular Function, Left
Chemical
Reg. No./Substance:
7440-54-2/Gadolinium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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