| Anatomic magnetic resonance imaging of the developing child and adolescent brain and effects of genetic variation. | |
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MedLine Citation:
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PMID: 21069466 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Magnetic resonance imaging studies have begun to map effects of genetic variation on trajectories of brain development. Longitudinal studies of children and adolescents demonstrate a general pattern of childhood peaks of gray matter followed by adolescent declines, functional and structural increases in connectivity and integrative processing, and a changing balance between limbic/subcortical and frontal lobe functions, which extends well into young adulthood. Twin studies have demonstrated that genetic factors are responsible for a significant amount of variation in pediatric brain morphometry. Longitudinal studies have shown specific genetic polymorphisms affect rates of cortical changes associated with maturation. Although over-interpretation and premature application of neuroimaging findings for diagnostic purposes remains a risk, converging data from multiple imaging modalities is beginning to elucidate the influences of genetic factors on brain development and implications of maturational changes for cognition, emotion, and behavior. |
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Authors:
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Jay N Giedd; Michael Stockman; Catherine Weddle; Maria Liverpool; Aaron Alexander-Bloch; Gregory L Wallace; Nancy R Lee; Francois Lalonde; Rhoshel K Lenroot |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural; Review Date: 2010-11-11 |
Journal Detail:
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Title: Neuropsychology review Volume: 20 ISSN: 1573-6660 ISO Abbreviation: Neuropsychol Rev Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-24 Completed Date: 2011-03-08 Revised Date: 2012-02-01 |
Medline Journal Info:
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Nlm Unique ID: 9009029 Medline TA: Neuropsychol Rev Country: United States |
Other Details:
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Languages: eng Pagination: 349-61 Citation Subset: IM |
Affiliation:
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Child Psychiatry Branch, National Institutes of Mental Health, Bethesda, MD, USA. jg@nih.gov |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Age Factors Brain / anatomy & histology*, growth & development* Brain Mapping* Child Child Development / physiology* Environment Genetic Variation / physiology* Humans Magnetic Resonance Imaging* Models, Biological Neuronal Plasticity / genetics |
| Grant Support | |
ID/Acronym/Agency:
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Z99 MH999999/MH/NIMH NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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