| Anaplerotic molecules: current and future. | |
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MedLine Citation:
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PMID: 16763895 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This review presents the concepts of anaplerosis and cataplerosis in relation to the regulation of citric acid cycle operation. Anaplerosis is the re-filling of the catalytic intermediates of the cycle that carry acetyl-CoA as it is oxidized. The main anaplerotic substrates are pyruvate, glutamine/glutamate and precursors of propionyl-CoA (odd-chain fatty acids, specific amino acids, C(5)-ketone bodies). Cataplerosis balances anaplerosis by removing excess intermediates from the citric acid cycle. The properties of the main anaplerotic substrates are reviewed from the point of view of potential clinical applications to the treatment of some inherited and acquired conditions. |
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Authors:
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Henri Brunengraber; Charles R Roe |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Journal of inherited metabolic disease Volume: 29 ISSN: 1573-2665 ISO Abbreviation: J. Inherit. Metab. Dis. Publication Date: 2006 Apr-Jun |
Date Detail:
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Created Date: 2006-06-09 Completed Date: 2007-01-09 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7910918 Medline TA: J Inherit Metab Dis Country: Netherlands |
Other Details:
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Languages: eng Pagination: 327-31 Citation Subset: IM |
Affiliation:
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Department of Nutrition, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106-4906, USA. hxb8@case.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acyl Coenzyme A
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metabolism* Animals Citric Acid Cycle* Glutamic Acid / metabolism*, therapeutic use Glutamine / metabolism*, therapeutic use Heptanoates / metabolism Humans Ketone Bodies / metabolism Metabolism, Inborn Errors / diet therapy, metabolism Propionic Acids / metabolism Pyruvic Acid / metabolism*, therapeutic use Reperfusion Injury / metabolism Triglycerides / metabolism Valerates / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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HL074237/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Acyl Coenzyme A; 0/Heptanoates; 0/Ketone Bodies; 0/Propionic Acids; 0/Triglycerides; 0/Valerates; 127-17-3/Pyruvic Acid; 317-66-8/propionyl-coenzyme A; 56-85-9/Glutamine; 56-86-0/Glutamic Acid; 79-09-4/propionic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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