Document Detail

Anaplastic transformation of an atypical intraventricular meningioma with metastases to the liver: case report.
MedLine Citation:
PMID:  19967319     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Malignant intraventricular meningiomas are very rare. To the best of our knowledge, only eleven cases have been reported thus far. Seven of them developed cerebrospinal fluid (CSF) metastases. We present herein the first case of a malignant intraventricular meningioma with extraneural metastases. CLINICAL PRESENTATION: We report a 44 year-old-man with a history of progressive headache and disorientation. Magnetic resonance imaging (MRI) revealed a 5-cm homogeneously-enhancing mass in the right trigone. INTERVENTION: The lesion was totally resected via a parietooccipital transcortical approach. Histological examination demonstrated an atypical meningioma. Thereafter, the tumor recurred twice. At first recurrence, the tumor was completely removed again and external radiotherapy was administered. At surgery at second recurrence, the tumor was more aggressive, invading the brain parenchyma. Histological examination showed anaplastic meningioma. The patient was readmitted to hospital with fever and pain in right hypochondrium. Abdominal ultrasound examination disclosed multiple hypoechoic liver lesions. Biopsy was consistent with liver metastases of a malignant meningioma. The patient died of acute liver failure seven months after initial diagnosis. CONCLUSION: Malignant intraventricular meningiomas are prone to recur and develop metastases, mainly through the CSF. Nevertheless, our case shows that extraneural metastases are also possible. Therefore, when systemic deterioration occurs in a patient with a malignant intraventricular meningioma, metastases to extraneural organs such as the liver must be ruled out.
M Garcia-Conde; H Roldan-Delgado; D Martel-Barth-Hansen; C Manzano-Sanz
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Neurocirug?a (Asturias, Spain)     Volume:  20     ISSN:  1130-1473     ISO Abbreviation:  Neurocirugia (Astur)     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-07     Completed Date:  2010-04-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9425251     Medline TA:  Neurocirugia (Astur)     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  541-9     Citation Subset:  IM    
Department of Neurosurgery, Hospital Universitario de Canarias, Tenerife, Spain.
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MeSH Terms
Anaplasia / pathology*
Fatal Outcome
Liver Neoplasms / pathology,  secondary*
Magnetic Resonance Imaging / methods
Meningeal Neoplasms / pathology*
Meningioma / pathology*
Tomography, X-Ray Computed / methods

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