Document Detail

Anaplastic oligodendrogliomas after treatment of acute lymphoblastic leukemia in children: report of 2 cases.
MedLine Citation:
PMID:  20121367     Owner:  NLM     Status:  MEDLINE    
Radiation-induced brain tumors are suggested to be the late complication of acute lymphoblastic leukemia (ALL) treatment. High-grade gliomas, meningiomas, and sarcomas are the most frequent neoplasms. Secondary anaplastic oligodendrogliomas are exceedingly rare. Five cases of pure anaplastic oligodendroglioma have been reported in the literature, and only 1 case was in a child after ALL treatment. The authors present 2 cases of pediatric anaplastic oligodendroglioma after treatment of ALL. Furthermore, they performed a molecular cytogenetic study and found loss of 1p in both cases. The authors provide a review of the previous cases and discuss their findings.
George A Alexiou; Maria Moschovi; George Georgoulis; Rosalia Neroutsou; Kalliopi Stefanaki; George Sfakianos; Neofytos Prodromou
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of neurosurgery. Pediatrics     Volume:  5     ISSN:  1933-0715     ISO Abbreviation:  J Neurosurg Pediatr     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-03     Completed Date:  2010-02-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101463759     Medline TA:  J Neurosurg Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  179-83     Citation Subset:  IM    
Department of Neurosurgery, University of Athens, Athens, Greece.
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MeSH Terms
Brain Neoplasms / etiology*,  pathology,  surgery
Magnetic Resonance Imaging
Neoplasm Proteins / biosynthesis
Neurosurgical Procedures
Oligodendroglioma / etiology*,  pathology,  surgery
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / complications*,  radiotherapy*
Radiotherapy / adverse effects*
Treatment Outcome
Reg. No./Substance:
0/Neoplasm Proteins

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