Document Detail


Anaplastic oligoastrocytoma in Turcot syndrome.
MedLine Citation:
PMID:  19495563     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Turcot syndrome (TS), a rare variant of hereditary non-polyposis colorectal cancer (HNPCC), is characterized by familial clustering of cancer of the large bowel, extracolonic body sites and brain. It is caused by germline mutations in genes encoding for components of the DNA mismatch repair system. We report a 72 year old woman with anaplastic oligoastrocytoma in the setting of TS. Careful analysis of tumor DNA is required to exclude the chance occurrence of a brain tumor in HNPCC kindreds and increase our understanding of the pathogenesis of the disease. Our case adds to the handful of cases published with detailed molecular data previously.
Authors:
Joachim Baehring; Pei Hui; Joseph Piepmeier; Serguei I Bannykh
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-06-04
Journal Detail:
Title:  Journal of neuro-oncology     Volume:  95     ISSN:  1573-7373     ISO Abbreviation:  J. Neurooncol.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-08     Completed Date:  2009-12-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309335     Medline TA:  J Neurooncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  293-8     Citation Subset:  IM    
Affiliation:
Department of Neurology, Yale University School of Medicine, 333 Cedar Street, TMP412, New Haven, CT 06510, USA. joachim.baehring@yale.edu
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MeSH Terms
Descriptor/Qualifier:
Adaptor Proteins, Signal Transducing / genetics,  metabolism
Adenosine Triphosphatases / genetics,  metabolism
Aged
Astrocytoma / complications*,  metabolism,  pathology
Colorectal Neoplasms, Hereditary Nonpolyposis / complications*,  metabolism,  pathology
DNA Repair Enzymes / genetics,  metabolism
DNA, Neoplasm / genetics
DNA-Binding Proteins / genetics,  metabolism
Female
Humans
Immunoenzyme Techniques
Magnetic Resonance Imaging
MutS Homolog 2 Protein / genetics
Nuclear Proteins / genetics,  metabolism
Pedigree
Polymerase Chain Reaction
Chemical
Reg. No./Substance:
0/Adaptor Proteins, Signal Transducing; 0/DNA, Neoplasm; 0/DNA-Binding Proteins; 0/G-T mismatch-binding protein; 0/MLH1 protein, human; 0/Nuclear Proteins; EC 3.6.1.-/Adenosine Triphosphatases; EC 3.6.1.-/PMS2 protein, human; EC 3.6.1.3/MSH2 protein, human; EC 3.6.1.3/MutS Homolog 2 Protein; EC 6.5.1.-/DNA Repair Enzymes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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