| Anaplastic oligoastrocytoma in Turcot syndrome. | |
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MedLine Citation:
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PMID: 19495563 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Turcot syndrome (TS), a rare variant of hereditary non-polyposis colorectal cancer (HNPCC), is characterized by familial clustering of cancer of the large bowel, extracolonic body sites and brain. It is caused by germline mutations in genes encoding for components of the DNA mismatch repair system. We report a 72 year old woman with anaplastic oligoastrocytoma in the setting of TS. Careful analysis of tumor DNA is required to exclude the chance occurrence of a brain tumor in HNPCC kindreds and increase our understanding of the pathogenesis of the disease. Our case adds to the handful of cases published with detailed molecular data previously. |
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Authors:
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Joachim Baehring; Pei Hui; Joseph Piepmeier; Serguei I Bannykh |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2009-06-04 |
Journal Detail:
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Title: Journal of neuro-oncology Volume: 95 ISSN: 1573-7373 ISO Abbreviation: J. Neurooncol. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-10-08 Completed Date: 2009-12-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8309335 Medline TA: J Neurooncol Country: United States |
Other Details:
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Languages: eng Pagination: 293-8 Citation Subset: IM |
Affiliation:
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Department of Neurology, Yale University School of Medicine, 333 Cedar Street, TMP412, New Haven, CT 06510, USA. joachim.baehring@yale.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptor Proteins, Signal Transducing
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genetics,
metabolism Adenosine Triphosphatases / genetics, metabolism Aged Astrocytoma / complications*, metabolism, pathology Colorectal Neoplasms, Hereditary Nonpolyposis / complications*, metabolism, pathology DNA Repair Enzymes / genetics, metabolism DNA, Neoplasm / genetics DNA-Binding Proteins / genetics, metabolism Female Humans Immunoenzyme Techniques Magnetic Resonance Imaging MutS Homolog 2 Protein / genetics Nuclear Proteins / genetics, metabolism Pedigree Polymerase Chain Reaction |
| Chemical | |
Reg. No./Substance:
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0/Adaptor Proteins, Signal Transducing; 0/DNA, Neoplasm; 0/DNA-Binding Proteins; 0/G-T mismatch-binding protein; 0/MLH1 protein, human; 0/Nuclear Proteins; EC 3.6.1.-/Adenosine Triphosphatases; EC 3.6.1.-/PMS2 protein, human; EC 3.6.1.3/MSH2 protein, human; EC 3.6.1.3/MutS Homolog 2 Protein; EC 6.5.1.-/DNA Repair Enzymes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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