Document Detail

Anaplastic large cell lymphoma presenting as acute liver failure: A report of two cases with review of literature.
MedLine Citation:
PMID:  21057166     Owner:  NLM     Status:  MEDLINE    
Primary hepatic anaplastic large cell lymphoma (ALCL) of the liver is a rare entity. We present here two cases of primary hepatic anaplastic large cell lymphoma (ALCL) of the null-cell type. Both the cases had jaundice with "B" symptoms and hepatomegaly. The serum billirubin and liver enzymes were raised in both cases. The liver showed sinusoidal infiltration by atypical lymphoid cells with marked nuclear pleomorphism, dispersed chromatin and prominent nucleoli in both the cases. These cells were positive for CD30, negative for CD3, CD20 and EMA, and diagnosed as ALCL of the null-cell type. We hereby report these cases with the review of literature on primary hepatic ALCLwith their possible etio-pathogenesis & diagnostic clues which may help in timely diagnosis & management in such cases.
Uma Nahar Saikia; Nidhi Sharma; Ajay Duseja; Ashish Bhalla; Kusum Joshi
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Annals of hepatology     Volume:  9     ISSN:  1665-2681     ISO Abbreviation:  Ann Hepatol     Publication Date:    2010 Oct-Dec
Date Detail:
Created Date:  2010-11-08     Completed Date:  2011-02-17     Revised Date:  2013-05-16    
Medline Journal Info:
Nlm Unique ID:  101155885     Medline TA:  Ann Hepatol     Country:  Mexico    
Other Details:
Languages:  eng     Pagination:  457-61     Citation Subset:  IM    
Departments of Histopathology, Hepatology and Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
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MeSH Terms
Antigens, CD30 / metabolism
Bilirubin / blood
Diagnosis, Differential
Fatal Outcome
Liver / enzymology,  pathology
Liver Failure, Acute / diagnosis*,  metabolism,  pathology
Liver Neoplasms / diagnosis*,  metabolism,  pathology
Lymphoma, Large-Cell, Anaplastic / diagnosis*,  metabolism,  pathology
Reg. No./Substance:
0/Antigens, CD30; 635-65-4/Bilirubin

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