| Anaplastic large cell lymphoma presenting as a pleural effusion and mimicking primary effusion lymphoma. A report of 2 cases. | |
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MedLine Citation:
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PMID: 14526684 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Systemic anaplastic large cell lymphoma (ALCL) is predominantly a nodal disease, but extranodal involvement can occur during the disease course or as the primary presentation. We report two rare cases of ALCL presenting with a pleural effusion, mimicking primary effusion lymphoma (PEL). CASES: Two patients, a 47-year-old woman and an 81-year-old man, presented with a pleural effusion for investigation. The pleural fluid contained abundant, large, lymphoid cells with marked nuclear atypia. These neoplastic cells strongly expressed CD30 and EMA and showed a T-cell phenotype (CD3+CD45RO+ for case 1 and CD4+ for case 2). Case 1, in addition, showed ALK1 expression. The tumor cells in both cases were negative for human herpes virus type 8 (HHV8) and Epstein-Barr virus (EBV). ALCL shows overlapping cytologic features with PEL, but the T-cell phenotype, ALK1 expression in case 1, lack of association with HHV8 and EBV, HIV seronegativity and subsequent discovery of nodal disease in case 2 were all in favor of ALCL over PEL. CONCLUSION: In rare cases a pleural effusion is the presenting feature of ALCL, and distinction from PEL depends on correlation with clinical findings, detailed immunophenotyping and study of the status of HHV8 and EBV. |
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Authors:
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Alexander Chak-Lam Chan; John Kwok-Cheung Chan; Kin Wing Yan; Yok Lam Kwong |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Acta cytologica Volume: 47 ISSN: 0001-5547 ISO Abbreviation: Acta Cytol. Publication Date: 2003 Sep-Oct |
Date Detail:
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Created Date: 2003-10-06 Completed Date: 2003-10-17 Revised Date: 2011-06-08 |
Medline Journal Info:
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Nlm Unique ID: 0370307 Medline TA: Acta Cytol Country: United States |
Other Details:
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Languages: eng Pagination: 809-16 Citation Subset: IM |
Affiliation:
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Department of Pathology, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong. chancl@ha.org.hk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Antigens, CD / metabolism Diagnosis, Differential Female Humans Immunoenzyme Techniques Immunophenotyping Lymphoma, Large-Cell, Anaplastic / diagnosis*, enzymology Male Middle Aged Pleural Effusion, Malignant / diagnosis*, enzymology Protein-Tyrosine Kinases / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; EC 2.7.10.1/Protein-Tyrosine Kinases; EC 2.7.10.1/anaplastic lymphoma kinase |
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