Document Detail


Anaplasma phagocytophilum, interferon gamma production and Stat1 signaling.
MedLine Citation:
PMID:  23278812     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human granulocytic anaplasmosis is caused by the obligate intracellular bacterium, Anaplasma phagocytophilum. The proinflammatory cytokine, IFN-γ, is necessary for innate immunity and plays an important role in the induction of severe histopathology in A. phagocytophilum-infected mice, horses and humans. In this study, activation of signal transducer and activator of transcription (Stat) 1 phosphorylation associated with A. phagocytophilum infection was examined in mice and found to be markedly greater on day 7 post-infection than in mock-infected controls. This increase in phosphorylated Stat1 (pStat1) correlated significantly with IFN-γ production and inflammatory tissue injury. Because pStat1 operates as a transcription factor central to the generation of effectors of inflammatory injury, these data suggest that Stat1 signaling is involved in IFN-γ-mediated immunopathologic lesions and disease in A. phagocytophilum infection and could be an important target for intervention in this disease.
Authors:
Kyoung-Seong Choi; J Stephen Dumler
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Microbiology and immunology     Volume:  57     ISSN:  1348-0421     ISO Abbreviation:  Microbiol. Immunol.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-15     Completed Date:  2013-08-26     Revised Date:  2014-11-04    
Medline Journal Info:
Nlm Unique ID:  7703966     Medline TA:  Microbiol Immunol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  207-12     Citation Subset:  IM    
Copyright Information:
© 2012 The Societies and Wiley Publishing Asia Pty Ltd.
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MeSH Terms
Descriptor/Qualifier:
Anaplasma phagocytophilum / immunology*
Animals
Disease Models, Animal
Ehrlichiosis / immunology*
Female
Interferon-gamma / secretion*
Mice
Mice, Inbred C57BL
STAT1 Transcription Factor / biosynthesis*
Signal Transduction*
Grant Support
ID/Acronym/Agency:
R01 AI41213/AI/NIAID NIH HHS; R21 AI096062/AI/NIAID NIH HHS; R21 AI096062/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/STAT1 Transcription Factor; 0/Stat1 protein, mouse; 82115-62-6/Interferon-gamma
Comments/Corrections

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