| Anaplasma phagocytophilum, Interferon gamma production and Stat1 signaling. | |
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MedLine Citation:
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PMID: 23278812 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Human granulocytic anaplasmosis (HGA) is caused by the obligate intracellular bacterium, Anaplasma phagocytophilum. The proinflammatory cytokine, IFN-γ is necessary for innate immunity and plays an important role in the induction of severe histopathology in A. phagocytophilum-infected mice and disease in horses and humans. In this study, we examined the role of activation of signal transducer and activator of transcription (Stat) 1 phosphorylation with A. phagocytophilum infection, and found it to be markedly increased at day 7 post infection compared to mock-infected controls. This increase in phosphorylated Stat1 (pStat1) was significantly correlated with IFN-γ production and inflammatory tissue injury. Since pStat1 operates as a transcription factor central to the generation of effectors of inflammatory injury, these data suggest that Stat1 signaling is involved in IFN-γ-mediated immunopathologic lesions and disease in A. phagocytophilum infection and could be an important target for intervention of disease. |
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Authors:
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Kyoung-Seong Choi; J Stephen Dumler |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-28 |
Journal Detail:
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Title: Microbiology and immunology Volume: - ISSN: 1348-0421 ISO Abbreviation: Microbiol. Immunol. Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2013-1-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7703966 Medline TA: Microbiol Immunol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 The Societies and Blackwell Publishing Asia Pty Ltd. |
Affiliation:
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School of Animal Science and Biotechnology, College of Ecology and Environmental Science, Kyungpook National University, Sangju 742-711, Republic of Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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