Document Detail


Anaplasma phagocytophilum, Interferon gamma production and Stat1 signaling.
MedLine Citation:
PMID:  23278812     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Human granulocytic anaplasmosis (HGA) is caused by the obligate intracellular bacterium, Anaplasma phagocytophilum. The proinflammatory cytokine, IFN-γ is necessary for innate immunity and plays an important role in the induction of severe histopathology in A. phagocytophilum-infected mice and disease in horses and humans. In this study, we examined the role of activation of signal transducer and activator of transcription (Stat) 1 phosphorylation with A. phagocytophilum infection, and found it to be markedly increased at day 7 post infection compared to mock-infected controls. This increase in phosphorylated Stat1 (pStat1) was significantly correlated with IFN-γ production and inflammatory tissue injury. Since pStat1 operates as a transcription factor central to the generation of effectors of inflammatory injury, these data suggest that Stat1 signaling is involved in IFN-γ-mediated immunopathologic lesions and disease in A. phagocytophilum infection and could be an important target for intervention of disease.
Authors:
Kyoung-Seong Choi; J Stephen Dumler
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-28
Journal Detail:
Title:  Microbiology and immunology     Volume:  -     ISSN:  1348-0421     ISO Abbreviation:  Microbiol. Immunol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2013-1-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7703966     Medline TA:  Microbiol Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Societies and Blackwell Publishing Asia Pty Ltd.
Affiliation:
School of Animal Science and Biotechnology, College of Ecology and Environmental Science, Kyungpook National University, Sangju 742-711, Republic of Korea.
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