Document Detail

Anaphylaxis to cefazolin during labor secondary to prophylaxis for group B Streptococcus: a case report.
MedLine Citation:
PMID:  16967637     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Anaphylaxis is an uncommon event during pregnancy, but if it does arise, it can lead to serious fetal consequences even if there are no serious long-term maternal complications. CASE: A parturient developed anaphylaxis in the labor unit shortly after intravenous cefazolin chemoprophylaxis had begun for perinatal group B streptococcal disease. Prompt treatment for anaphylaxis commenced, involving the administration of epinephrine and glucocorticoids, and an emergency cesarean section spared the mother serious morbidity, with a favorable perinatal outcome for the fetus. CONCLUSION: To the best of our knowledge, this case is the first reported one of anaphylaxis to cefazolin in pregnancy secondary to prophylaxis against for B Streptococcus. The case demonstrates that a life-threatening anaphylactic reaction can occur at any time during pregnancy and that all staff in a maternal unit should be familiar with the management of perinatal anaphylaxis.
Mei-Shan Jao; Po-Jen Cheng; Sheng-Wen Shaw; Yung-Kuei Soong
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of reproductive medicine     Volume:  51     ISSN:  0024-7758     ISO Abbreviation:  J Reprod Med     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-09-13     Completed Date:  2007-07-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0173343     Medline TA:  J Reprod Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  655-8     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, 5, Fu-Shin Street, Kwei-Shan, Tao-Yuan, 333 Taiwan, ROC.
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MeSH Terms
Anti-Bacterial Agents / immunology*,  therapeutic use
Antibiotic Prophylaxis
Cefazolin / immunology*,  therapeutic use
Cesarean Section
Obstetric Labor Complications / chemically induced*,  immunology
Pregnancy Outcome
Streptococcal Infections / drug therapy,  prevention & control*
Streptococcus agalactiae*
Reg. No./Substance:
0/Anti-Bacterial Agents; 25953-19-9/Cefazolin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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