Document Detail

Anaphylaxis to apple: is fasting a risk factor for LTP-allergic patients?
MedLine Citation:
PMID:  21114199     Owner:  NLM     Status:  In-Process    
BACKGROUND: Primary apple allergy is frequent in Mediterranean countries where hypersensitivity to lipid transfer protein (LTP) is common. Due to its stability upon pepsin digestion, LTP may cause systemic allergic reactions. This study investigated the potential risk associated with an isolated intake of apple while fasting in LTP-hypersensitive patients with clinical allergy to peach but not to apple.
PATIENTS AND METHODS: Based on the observation of 6 patients who experienced 7 apple-induced anaphylactic reactions that in 6 cases followed the ingestion of the fruit after fasting, open food challenges were carried out in 12 patients LTP-hypersensitive patients with peach allergy but tolerant to apple.
RESULTS: Four out of the 12 patients (33%) reacted to apple upon oral challenge.
CONCLUSION: Fasting seems to play a relevant role in the clinical expression of allergy to LTP. It is possible that in an empty gastrointestinal tract the allergen is absorbed more rapidly. Alternatively, pepsin might digest the food matrix more efficiently, thus increasing the concentration of the purified allergen that comes in contact with the gut mucosa.
A Arena
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European annals of allergy and clinical immunology     Volume:  42     ISSN:  1764-1489     ISO Abbreviation:  Eur Ann Allergy Clin Immunol     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-11-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101466614     Medline TA:  Eur Ann Allergy Clin Immunol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  155-8     Citation Subset:  IM    
Ambulatorio di Allergologia, Azienda Sanitaria Provinciale di Messina.
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