| Anaphylaxis syndromes related to a new mammalian cross-reactive carbohydrate determinant. | |
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MedLine Citation:
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PMID: 19815111 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Anaphylaxis is a severe allergic reaction that can rapidly progress and occasionally be fatal. In instances in which the triggering allergen is not obvious, establishing the cause of anaphylaxis is pivotal to long-term management. Assigning cause is limited, however, by the number of known exposures associated with anaphylaxis. Therefore identification of novel causative agents can provide an important step forward in facilitating new, allergen-specific approaches to management. In contrast to the view that carbohydrate-directed IgE has minimal, if any, clinical significance, recent data suggest that IgE antibodies to carbohydrate epitopes can be an important factor in anaphylaxis that might otherwise appear to be idiopathic. Here we review the evidence relating to carbohydrates in food allergy and anaphylaxis and discuss the implications of a new mammalian cross-reactive carbohydrate determinant. |
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Authors:
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Scott P Commins; Thomas A E Platts-Mills |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The Journal of allergy and clinical immunology Volume: 124 ISSN: 1097-6825 ISO Abbreviation: J. Allergy Clin. Immunol. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-10-09 Completed Date: 2009-11-13 Revised Date: 2013-05-31 |
Medline Journal Info:
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Nlm Unique ID: 1275002 Medline TA: J Allergy Clin Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 652-7 Citation Subset: AIM; IM |
Affiliation:
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Asthma and Allergic Diseases Center, University of Virginia Health System, Charlottesville, USA. spc7w@virginia.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Allergens
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immunology Anaphylaxis / diagnosis, immunology*, metabolism, therapy Animals Carbohydrates / immunology* Cross Reactions / immunology Desensitization, Immunologic Disaccharides / immunology*, metabolism Food Hypersensitivity / diagnosis, immunology*, metabolism Glycosylation Humans Immunodominant Epitopes / immunology Immunoglobulin E / immunology*, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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R01 AI020565-25/AI/NIAID NIH HHS; U19 AI070364-01/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Allergens; 0/Carbohydrates; 0/Disaccharides; 0/Immunodominant Epitopes; 13168-24-6/galactosyl-(1-3)galactose; 37341-29-0/Immunoglobulin E |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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