Document Detail

Anaphylaxis syndromes related to a new mammalian cross-reactive carbohydrate determinant.
MedLine Citation:
PMID:  19815111     Owner:  NLM     Status:  MEDLINE    
Anaphylaxis is a severe allergic reaction that can rapidly progress and occasionally be fatal. In instances in which the triggering allergen is not obvious, establishing the cause of anaphylaxis is pivotal to long-term management. Assigning cause is limited, however, by the number of known exposures associated with anaphylaxis. Therefore identification of novel causative agents can provide an important step forward in facilitating new, allergen-specific approaches to management. In contrast to the view that carbohydrate-directed IgE has minimal, if any, clinical significance, recent data suggest that IgE antibodies to carbohydrate epitopes can be an important factor in anaphylaxis that might otherwise appear to be idiopathic. Here we review the evidence relating to carbohydrates in food allergy and anaphylaxis and discuss the implications of a new mammalian cross-reactive carbohydrate determinant.
Scott P Commins; Thomas A E Platts-Mills
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  124     ISSN:  1097-6825     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-09     Completed Date:  2009-11-13     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  652-7     Citation Subset:  AIM; IM    
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MeSH Terms
Allergens / immunology
Anaphylaxis / diagnosis,  immunology*,  metabolism,  therapy
Carbohydrates / immunology*
Cross Reactions / immunology
Desensitization, Immunologic
Disaccharides / immunology*,  metabolism
Food Hypersensitivity / diagnosis,  immunology*,  metabolism
Immunodominant Epitopes / immunology
Immunoglobulin E / immunology*,  metabolism
Grant Support
R01 AI020565/AI/NIAID NIH HHS; R01 AI020565-25/AI/NIAID NIH HHS; U19 AI070364/AI/NIAID NIH HHS; U19 AI070364-01/AI/NIAID NIH HHS
Reg. No./Substance:
0/Allergens; 0/Carbohydrates; 0/Disaccharides; 0/Immunodominant Epitopes; 13168-24-6/galactosyl-(1-3)galactose; 37341-29-0/Immunoglobulin E

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