Document Detail

Anaphylaxis. A preventable emergency.
MedLine Citation:
PMID:  2181424     Owner:  NLM     Status:  MEDLINE    
Anaphylaxis is a life-threatening reaction that may be caused by a variety of agents. Diagnosis depends on the presence of a constellation of symptoms (eg, laryngeal edema, bronchospasm, hypotension, urticaria). The goal of therapy is maintenance of an effective airway, respiratory function, and circulation. Subcutaneous epinephrine, H1 and H2 antihistamines, and a prolonged period of observation (at least 8 hours) should be used in all patients. After the acute attack has been managed, a thorough investigation of possible causes should be made and the patient referred to a specialist, if indicated. Desensitization therapy, premedication before high-risk exposures, and careful avoidance of known causative agents are effective preventive measures. Direction in self-administration of epinephrine is critical in these patients and may prove lifesaving.
J Corren; A L Schocket
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Postgraduate medicine     Volume:  87     ISSN:  0032-5481     ISO Abbreviation:  Postgrad Med     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-05-10     Completed Date:  1990-05-10     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0401147     Medline TA:  Postgrad Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  167-8, 171-8     Citation Subset:  AIM; IM    
Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206.
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MeSH Terms
Acute Disease
Anaphylaxis / diagnosis*,  etiology,  therapy
Combined Modality Therapy
Diagnosis, Differential
Epinephrine / administration & dosage
Self Administration
Reg. No./Substance:

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