Document Detail

Anaphylaxis: lesson learned from five cases.
MedLine Citation:
PMID:  18838753     Owner:  NLM     Status:  MEDLINE    
Anaphylaxis is a severe hypersensitivity reaction. Its clinical manifestations vary, affecting several organs at once. Skin symptom is the most frequent manifestation; however, diagnosis of anaphylaxis will only be established when involving one or both vital organs, which are cardiovascular and respiratory system. Other symptom, such as that involving central nervous system or gastrointestinal tract, may accompany. We present five cases of anaphylaxis which vary in onset of symptoms, allergen, degree of severity, therapeutic response and clinical manifestation. Anaphylactic reaction to drugs in these cases is mainly manifested as anaphylactic shock and reaction to food allergen causing obstruction of respiratory tract. Four anaphylactic events occurred at home and only one occurred in a hospital, thus education on anaphylaxis to general community is very important, especially for the patients and their families. Prompt medical assistance in patients with anaphylactic symptoms determines their therapeutic response. Skin test prior to administration of cephalosporin does not give negative predictive value toward anaphylactic event.
Heru Sundaru; Sukamto Koesnoe; Jeffry Beta Tenggara; Ketut Suryana
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta medica Indonesiana     Volume:  40     ISSN:  0125-9326     ISO Abbreviation:  Acta Med Indones     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-10-07     Completed Date:  2009-02-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7901042     Medline TA:  Acta Med Indones     Country:  Indonesia    
Other Details:
Languages:  eng     Pagination:  146-50     Citation Subset:  IM    
Department of Internal Medicine, Faculty of Medicine University of Indonesia-dr.Cipto Mangunkusumo Hospital, Jalan Diponegoro no. 71, Jakarta.
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MeSH Terms
Bronchodilator Agents / therapeutic use
Drug Hypersensitivity / drug therapy*
Epinephrine / therapeutic use
Fatal Outcome
Histamine H1 Antagonists / therapeutic use
Histamine H2 Antagonists / therapeutic use
Pharmaceutical Preparations / adverse effects*
Prescription Drugs / adverse effects*
Risk Factors
Young Adult
Reg. No./Substance:
0/Bronchodilator Agents; 0/Histamine H1 Antagonists; 0/Histamine H2 Antagonists; 0/Pharmaceutical Preparations; 0/Prescription Drugs; 51-43-4/Epinephrine

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