| Anaphylaxis fatalities and admissions in Australia. | |
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MedLine Citation:
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PMID: 19117599 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Detailed data on fatal anaphylaxis are limited, with national anaphylaxis fatality data for the United Kingdom and food-induced anaphylaxis fatality data for the United States. Time trends for anaphylaxis fatalities are not available. OBJECTIVE: We examined causes, demographics, and time trends for anaphylaxis fatalities in Australia between January 1997 and December 2005 and compared these with findings for anaphylaxis admissions. METHODS: Data on anaphylaxis deaths and hospital admissions were extracted from a national database. Death certificate codes were analyzed to determine the likely cause and associated comorbidities. RESULTS: There were 112 anaphylaxis fatalities in Australia over 9 years. Causes were as follows: food, 7 (6%); drugs, 22 (20%); probable drugs, 42 (38%); insect stings, 20 (18%); undetermined, 15 (13%); and other, 6 (5%). All food-induced anaphylaxis fatalities occurred between 8 and 35 years of age with female preponderance, despite the majority of food-induced anaphylaxis admissions occurring in children less than 5 years of age. Most insect sting-induced anaphylaxis deaths occurred between 35 and 84 years almost exclusively in male subjects, although bee sting-induced admissions peak between 5 and 9 years of age with a male/female ratio of 2.7. However, most drug-induced anaphylaxis deaths occurred between 55 and 85 years with equal sex distribution similar to drug-induced anaphylaxis admissions. There was no evidence of an increase in death rates for food-induced anaphylaxis, despite food-induced anaphylaxis admissions increasing approximately 350%. In contrast, drug-induced anaphylaxis deaths increased approximately 300% compared with an approximately 150% increase in drug-induced anaphylaxis admissions. CONCLUSION: The demographics for anaphylaxis deaths are different to those for anaphylaxis presentations. Anaphylaxis mortality rates remain low and stable, despite increasing anaphylaxis prevalence, with the exception of drug-induced anaphylaxis deaths, which have increased. |
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Authors:
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Woei Kang Liew; Elizabeth Williamson; Mimi L K Tang |
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Publication Detail:
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Type: Journal Article Date: 2008-12-30 |
Journal Detail:
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Title: The Journal of allergy and clinical immunology Volume: 123 ISSN: 1097-6825 ISO Abbreviation: J. Allergy Clin. Immunol. Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-02-10 Completed Date: 2009-03-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1275002 Medline TA: J Allergy Clin Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 434-42 Citation Subset: AIM; IM |
Affiliation:
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Department of Allergy and Immunology, Melbourne, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Allergens / immunology Anaphylaxis / epidemiology, etiology, mortality* Australia / epidemiology Child Child, Preschool Drug Hypersensitivity / immunology, mortality* Female Food Hypersensitivity / immunology, mortality* Humans Insect Bites and Stings / immunology, mortality* Male Patient Admission / statistics & numerical data*, trends Risk Factors Sex Factors Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Allergens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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