Document Detail

Anaphylaxis fatalities and admissions in Australia.
MedLine Citation:
PMID:  19117599     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Detailed data on fatal anaphylaxis are limited, with national anaphylaxis fatality data for the United Kingdom and food-induced anaphylaxis fatality data for the United States. Time trends for anaphylaxis fatalities are not available. OBJECTIVE: We examined causes, demographics, and time trends for anaphylaxis fatalities in Australia between January 1997 and December 2005 and compared these with findings for anaphylaxis admissions. METHODS: Data on anaphylaxis deaths and hospital admissions were extracted from a national database. Death certificate codes were analyzed to determine the likely cause and associated comorbidities. RESULTS: There were 112 anaphylaxis fatalities in Australia over 9 years. Causes were as follows: food, 7 (6%); drugs, 22 (20%); probable drugs, 42 (38%); insect stings, 20 (18%); undetermined, 15 (13%); and other, 6 (5%). All food-induced anaphylaxis fatalities occurred between 8 and 35 years of age with female preponderance, despite the majority of food-induced anaphylaxis admissions occurring in children less than 5 years of age. Most insect sting-induced anaphylaxis deaths occurred between 35 and 84 years almost exclusively in male subjects, although bee sting-induced admissions peak between 5 and 9 years of age with a male/female ratio of 2.7. However, most drug-induced anaphylaxis deaths occurred between 55 and 85 years with equal sex distribution similar to drug-induced anaphylaxis admissions. There was no evidence of an increase in death rates for food-induced anaphylaxis, despite food-induced anaphylaxis admissions increasing approximately 350%. In contrast, drug-induced anaphylaxis deaths increased approximately 300% compared with an approximately 150% increase in drug-induced anaphylaxis admissions. CONCLUSION: The demographics for anaphylaxis deaths are different to those for anaphylaxis presentations. Anaphylaxis mortality rates remain low and stable, despite increasing anaphylaxis prevalence, with the exception of drug-induced anaphylaxis deaths, which have increased.
Woei Kang Liew; Elizabeth Williamson; Mimi L K Tang
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Publication Detail:
Type:  Journal Article     Date:  2008-12-30
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  123     ISSN:  1097-6825     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-10     Completed Date:  2009-03-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  434-42     Citation Subset:  AIM; IM    
Department of Allergy and Immunology, Melbourne, Australia.
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MeSH Terms
Allergens / immunology
Anaphylaxis / epidemiology,  etiology,  mortality*
Australia / epidemiology
Child, Preschool
Drug Hypersensitivity / immunology,  mortality*
Food Hypersensitivity / immunology,  mortality*
Insect Bites and Stings / immunology,  mortality*
Patient Admission / statistics & numerical data*,  trends
Risk Factors
Sex Factors
Young Adult
Reg. No./Substance:

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