Document Detail

Anaphylaxis during anesthesia in Norway: a 6-year single-center follow-up study.
MedLine Citation:
PMID:  15851874     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Several studies have recognized neuromuscular blocking agents as the most common cause of anaphylaxis during general anesthesia, but the reported frequencies vary considerably between countries. In Norway, the issue has raised special concern because of reports from the Norwegian Medicines Agency that suggest a high prevalence. This article presents the results from a standardized allergy follow-up examination of 83 anaphylactic reactions related to general anesthesia performed at one allergy center in Bergen, Norway. METHODS: Eighty-three cases were examined during the 6-yr period of 1996-2001. The diagnostic protocol consisted of case history, serum tryptase measurements, specific immunoassays, and skin tests. RESULTS: Immunoglobulin E-mediated anaphylaxis was established in 71.1% of the cases, and neuromuscular blocking agents were by far the most frequent allergen (93.2%). Suxamethonium was the most frequently involved substance, followed by rocuronium and vecuronium. The few reactions in which other allergies could be detected were mainly linked to latex (3.6%). CONCLUSIONS: Neuromuscular blocking agents were the dominating antigens causing immunoglobulin E-mediated anaphylaxis in this study. The data could not be used for estimation of the incidence of allergy toward neuromuscular blocking agents in Norway. Larger patient samples, standardization of reporting, and diagnostic protocols should be pursued by network formation to produce data more suitable for epidemiologic research.
Torkel Harboe; Anne Berit Guttormsen; Aagot Irgens; Turid Dybendal; Erik Florvaag
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anesthesiology     Volume:  102     ISSN:  0003-3022     ISO Abbreviation:  Anesthesiology     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-04-26     Completed Date:  2005-06-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  897-903     Citation Subset:  AIM; IM    
Department of Anesthesia and Intensive Care, Haukeland University Hospital, Bergen, Norway.
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MeSH Terms
Anaphylaxis / diagnosis,  epidemiology*
Anesthesia / adverse effects*
Anesthetics / adverse effects
Drug Hypersensitivity / epidemiology
Follow-Up Studies
Histamine Release / drug effects
Immunoglobulin E / analysis
Neuromuscular Blocking Agents / adverse effects*
Norway / epidemiology
Quaternary Ammonium Compounds / blood
Serine Endopeptidases / blood
Skin Tests
Reg. No./Substance:
0/Anesthetics; 0/Neuromuscular Blocking Agents; 0/Quaternary Ammonium Compounds; 37341-29-0/Immunoglobulin E; EC 3.4.21.-/Serine Endopeptidases; EC

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