| Anaphylaxis during anesthesia in Norway: a 6-year single-center follow-up study. | |
MedLine Citation:
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PMID: 15851874 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Several studies have recognized neuromuscular blocking agents as the most common cause of anaphylaxis during general anesthesia, but the reported frequencies vary considerably between countries. In Norway, the issue has raised special concern because of reports from the Norwegian Medicines Agency that suggest a high prevalence. This article presents the results from a standardized allergy follow-up examination of 83 anaphylactic reactions related to general anesthesia performed at one allergy center in Bergen, Norway. METHODS: Eighty-three cases were examined during the 6-yr period of 1996-2001. The diagnostic protocol consisted of case history, serum tryptase measurements, specific immunoassays, and skin tests. RESULTS: Immunoglobulin E-mediated anaphylaxis was established in 71.1% of the cases, and neuromuscular blocking agents were by far the most frequent allergen (93.2%). Suxamethonium was the most frequently involved substance, followed by rocuronium and vecuronium. The few reactions in which other allergies could be detected were mainly linked to latex (3.6%). CONCLUSIONS: Neuromuscular blocking agents were the dominating antigens causing immunoglobulin E-mediated anaphylaxis in this study. The data could not be used for estimation of the incidence of allergy toward neuromuscular blocking agents in Norway. Larger patient samples, standardization of reporting, and diagnostic protocols should be pursued by network formation to produce data more suitable for epidemiologic research. |
Authors:
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Torkel Harboe; Anne Berit Guttormsen; Aagot Irgens; Turid Dybendal; Erik Florvaag |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Anesthesiology Volume: 102 ISSN: 0003-3022 ISO Abbreviation: Anesthesiology Publication Date: 2005 May |
Date Detail:
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Created Date: 2005-04-26 Completed Date: 2005-06-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1300217 Medline TA: Anesthesiology Country: United States |
Other Details:
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Languages: eng Pagination: 897-903 Citation Subset: AIM; IM |
Affiliation:
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Department of Anesthesia and Intensive Care, Haukeland University Hospital, Bergen, Norway. torkel.harboe@helse-bergen.no |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anaphylaxis / diagnosis, epidemiology* Anesthesia / adverse effects* Anesthetics / adverse effects Drug Hypersensitivity / epidemiology Female Follow-Up Studies Histamine Release / drug effects Humans Immunoglobulin E / analysis Male Neuromuscular Blocking Agents / adverse effects* Norway / epidemiology Quaternary Ammonium Compounds / blood Serine Endopeptidases / blood Skin Tests Tryptases |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics; 0/Neuromuscular Blocking Agents; 0/Quaternary Ammonium Compounds; 37341-29-0/Immunoglobulin E; EC 3.4.21.-/Serine Endopeptidases; EC 3.4.21.59/Tryptases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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