Document Detail

Anaphylaxis after ingestion of wheat flour contaminated with mites.
MedLine Citation:
PMID:  9058685     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Anaphylaxis after ingestion of flours contaminated with mites has been recently reported. OBJECTIVE: The study was designed to determine whether four-induced reactions in the absence of food sensitivity may result from mite contamination. METHODS: Patients with systemic reactions after ingestion of foods containing wheat flour and without food sensitivities were included in a prospective study. The flours were examined microscopically, and major Dermatophagoides allergens were quantified by monoclonal antibody techniques. Skin prick tests and IgE determinations to mites and flours were performed. Single-blind, placebo-controlled oral challenges were also performed. RESULTS: Sixteen patients were included in our protocol. They showed respiratory allergies to dust mites (100%) and intolerance to acetylsalicylic acid (87%). Microscopic examination of four flours implicated in allergic reactions revealed a high degree of mite contamination: Dermatophagoides farinae in one case and Thyreophagus entomophagus in three cases. Our patients' skin test and specific IgE responses to the flours implicated in the reactions were positive. A high level of Der 2 was found in the flour infested by D. farinae. Three of six food challenges with contaminated flours resulted in systemic reactions. Good tolerance to control flours was shown in our patients. CONCLUSION: Ingestion of foods contaminated with mites may induce systemic anaphylactic reactions in patients with respiratory allergy to mites.
C Blanco; J Quiralte; R Castillo; J Delgado; C Arteaga; D Barber; T Carrillo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  99     ISSN:  0091-6749     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-04-04     Completed Date:  1997-04-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  308-13     Citation Subset:  AIM; IM    
Hospital Universitario Nuestra Señora del Pino, Facultad de Ciencias Médicas y de la Salud, Las Palmas de Gran Canaria, Canary Islands, Spain.
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MeSH Terms
Allergens / immunology
Anaphylaxis / immunology*
Antibodies, Monoclonal / immunology
Antigens, Dermatophagoides
Aspirin / adverse effects
Drug Hypersensitivity
Flour / adverse effects*,  analysis
Food Contamination*
Glycoproteins / analysis,  immunology
Hypersensitivity / immunology*
Immunoglobulin E / analysis
Mite Infestations / immunology*
Mites / immunology*
Prospective Studies
Respiratory Hypersensitivity / complications*,  diagnosis,  immunology
Skin Tests
Reg. No./Substance:
0/Allergens; 0/Antibodies, Monoclonal; 0/Antigens, Dermatophagoides; 0/Glycoproteins; 37341-29-0/Immunoglobulin E; 50-78-2/Aspirin

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