Document Detail


Anaphylaxis: an update on its understanding and management.
MedLine Citation:
PMID:  20100165     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Anaphylaxis is the most concerning manifestation of hypersensitivity. Recent thorough investigations on the pathophysiology of anaphylaxis achieved important advances in its understanding, regarding in particular the emerging role of mediators such as platelet activating factor (PAF) and sphyngosine 1 phosphate (S1P) and the improved knowledge on the actors of the signaling cascade, from the contact between the specific allergen and the IgE fixed on the Fc-epsilon-RI receptor to the opening of calcium channels. These advances may provide new diagnostic and therapeutical tools. In particular, a role for PAF and S1P as laboratory markers of anaphylaxis is likely to be developed, and innovative preventive strategies able to induce a negative signaling are currently under evaluation. Also, using well known preventive treatments, such as allergen specific immunotherapy may offer new perspectives for the management of patients at risk of potentially fatal reaction to foods. In fact, controlled studies demonstrated that sublingual immunotherapy is able to significantly increase the tolerance to the causative foods, fulfilling the need and protecting the allergic subject from anaphylaxis caused by accidental ingestion of small food amounts. The article also presented some promising patents on anaphylaxis.
Authors:
Cristoforo Incorvaia; Marina Mauro; Valerio Pravettoni; Stefano Incorvaia; Gian G Riario-Sforza
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Recent patents on inflammation & allergy drug discovery     Volume:  4     ISSN:  1872-213X     ISO Abbreviation:  Recent Pat Inflamm Allergy Drug Discov     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-07     Completed Date:  2010-08-06     Revised Date:  2011-06-17    
Medline Journal Info:
Nlm Unique ID:  101309297     Medline TA:  Recent Pat Inflamm Allergy Drug Discov     Country:  United Arab Emirates    
Other Details:
Languages:  eng     Pagination:  124-9     Citation Subset:  IM    
Affiliation:
Allergy/Pulmonary Rehabilitation, Istituti Clinici di Perfezionamento Hospital, Milan, Italy. cristoforo.incorvaia@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Anaphylaxis / diagnosis,  immunology,  therapy*
Animals
Food Hypersensitivity / diagnosis,  immunology,  therapy*
Humans
Immunotherapy / methods*
Lysophospholipids / metabolism
Patents as Topic
Platelet Activating Factor / metabolism
Signal Transduction / immunology
Sphingosine / analogs & derivatives,  metabolism
Chemical
Reg. No./Substance:
0/Lysophospholipids; 0/Platelet Activating Factor; 123-78-4/Sphingosine; 26993-30-6/sphingosine 1-phosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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